O'Brien A - Search Results

1

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors.

Chen KY, Krischuns T, Varga LO, Harigua-Souiai E, Paisant S, Zettor A, Chiaravalli J, Delpal A, Courtney D, O'Brien A, Baker SC, Decroly E, Isel C, Agou F, Jacob Y, Blondel A, Naffakh N. Chen KY, et al. Antiviral Res. 2022 May;201:105272. doi: 10.1016/j.antiviral.2022.105272. Epub 2022 Mar 9. Antiviral Res. 2022. PMID: 35278581 Free PMC article.

2

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.

Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC. Deng X, et al. J Virol. 2014 Oct;88(20):11886-98. doi: 10.1128/JVI.01528-14. Epub 2014 Aug 6. J Virol. 2014. PMID: 25100843 Free PMC article.

3

X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.

Clasman JR, Báez-Santos YM, Mettelman RC, O'Brien A, Baker SC, Mesecar AD. Clasman JR, et al. Sci Rep. 2017 Jan 12;7:40292. doi: 10.1038/srep40292. Sci Rep. 2017. PMID: 28079137 Free PMC article.

4

Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages.

Deng X, Hackbart M, Mettelman RC, O'Brien A, Mielech AM, Yi G, Kao CC, Baker SC. Deng X, et al. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4251-E4260. doi: 10.1073/pnas.1618310114. Epub 2017 May 8. Proc Natl Acad Sci U S A. 2017. PMID: 28484023 Free PMC article.

5

Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines.

O'Brien A, Mettelman RC, Volk A, André NM, Whittaker GR, Baker SC. O'Brien A, et al. Virology. 2018 Dec;525:1-9. doi: 10.1016/j.virol.2018.08.022. Epub 2018 Sep 8. Virology. 2018. PMID: 30205273 Free PMC article.

6

Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses.

Deng X, van Geelen A, Buckley AC, O'Brien A, Pillatzki A, Lager KM, Faaberg KS, Baker SC. Deng X, et al. J Virol. 2019 Apr 3;93(8):e02000-18. doi: 10.1128/JVI.02000-18. Print 2019 Apr 15. J Virol. 2019. PMID: 30728254 Free PMC article.

7

Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis.

Deng X, Mettelman RC, O'Brien A, Thompson JA, O'Brien TE, Baker SC. Deng X, et al. J Virol. 2019 May 29;93(12):e02140-18. doi: 10.1128/JVI.02140-18. Print 2019 Jun 15. J Virol. 2019. PMID: 30918076 Free PMC article.

8

Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus.

Mettelman RC, O'Brien A, Whittaker GR, Baker SC. Mettelman RC, et al. Virology. 2019 Nov;537:226-236. doi: 10.1016/j.virol.2019.08.030. Epub 2019 Aug 30. Virology. 2019. PMID: 31539770 Free PMC article.

9

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

Deng X, Chen Y, Mielech AM, Hackbart M, Kesely KR, Mettelman RC, O'Brien A, Chapman ME, Mesecar AD, Baker SC. Deng X, et al. J Virol. 2020 May 18;94(11):e01734-19. doi: 10.1128/JVI.01734-19. Print 2020 May 18. J Virol. 2020. PMID: 32188728 Free PMC article.

10

Coronavirus Endoribonuclease and Deubiquitinating Interferon Antagonists Differentially Modulate the Host Response during Replication in Macrophages.

Volk A, Hackbart M, Deng X, Cruz-Pulido Y, O'Brien A, Baker SC. Volk A, et al. J Virol. 2020 May 18;94(11):e00178-20. doi: 10.1128/JVI.00178-20. Print 2020 May 18. J Virol. 2020. PMID: 32188729 Free PMC article.

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