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Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern.
Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Li W, et al. Among authors: chen y. bioRxiv [Preprint]. 2021 Aug 3:2021.08.02.454546. doi: 10.1101/2021.08.02.454546. bioRxiv. 2021. Update in: Cell Rep. 2022 Jan 11;38(2):110210. doi: 10.1016/j.celrep.2021.110210 PMID: 34373853 Free PMC article. Updated. Preprint.
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.
Ullah I, Prévost J, Ladinsky MS, Stone H, Lu M, Anand SP, Beaudoin-Bussières G, Symmes K, Benlarbi M, Ding S, Gasser R, Fink C, Chen Y, Tauzin A, Goyette G, Bourassa C, Medjahed H, Mack M, Chung K, Wilen CB, Dekaban GA, Dikeakos JD, Bruce EA, Kaufmann DE, Stamatatos L, McGuire AT, Richard J, Pazgier M, Bjorkman PJ, Mothes W, Finzi A, Kumar P, Uchil PD. Ullah I, et al. Among authors: chen y. Immunity. 2021 Sep 14;54(9):2143-2158.e15. doi: 10.1016/j.immuni.2021.08.015. Epub 2021 Aug 18. Immunity. 2021. PMID: 34453881 Free PMC article.
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological and pathological disease in a Syrian hamster model of COVID-19.
Esparza TJ, Chen Y, Martin NP, Bielefeldt-Ohmann H, Bowen RA, Tolbert WD, Pazgier M, Brody DL. Esparza TJ, et al. Among authors: chen y. bioRxiv [Preprint]. 2021 Nov 12:2021.11.10.468147. doi: 10.1101/2021.11.10.468147. bioRxiv. 2021. Update in: MAbs. 2022 Jan-Dec;14(1):2047144. doi: 10.1080/19420862.2022.2047144 PMID: 34790977 Free PMC article. Updated. Preprint.
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.
Chen Y, Sun L, Ullah I, Beaudoin-Bussières G, Anand SP, Hederman AP, Tolbert WD, Sherburn R, Nguyen DN, Marchitto L, Ding S, Wu D, Luo Y, Gottumukkala S, Moran S, Kumar P, Piszczek G, Mothes W, Ackerman ME, Finzi A, Uchil PD, Gonzalez FJ, Pazgier M. Chen Y, et al. bioRxiv [Preprint]. 2021 Nov 24:2021.11.24.469776. doi: 10.1101/2021.11.24.469776. bioRxiv. 2021. Update in: Sci Adv. 2022 Jul 15;8(28):eabn4188. doi: 10.1126/sciadv.abn4188 PMID: 34845451 Free PMC article. Updated. Preprint.
Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.
Li W, Chen Y, Prévost J, Ullah I, Lu M, Gong SY, Tauzin A, Gasser R, Vézina D, Anand SP, Goyette G, Chaterjee D, Ding S, Tolbert WD, Grunst MW, Bo Y, Zhang S, Richard J, Zhou F, Huang RK, Esser L, Zeher A, Côté M, Kumar P, Sodroski J, Xia D, Uchil PD, Pazgier M, Finzi A, Mothes W. Li W, et al. Among authors: chen y. Cell Rep. 2022 Jan 11;38(2):110210. doi: 10.1016/j.celrep.2021.110210. Epub 2021 Dec 15. Cell Rep. 2022. PMID: 34971573 Free PMC article.
Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.
Tolbert WD, Nguyen DN, Tuyishime M, Crowley AR, Chen Y, Jha S, Goodman D, Bekker V, Mudrak SV, DeVico AL, Lewis GK, Theis JF, Pinter A, Moody MA, Easterhoff D, Wiehe K, Pollara J, Saunders KO, Tomaras GD, Ackerman M, Ferrari G, Pazgier M. Tolbert WD, et al. Among authors: chen y. Front Immunol. 2022 Jan 6;12:787603. doi: 10.3389/fimmu.2021.787603. eCollection 2021. Front Immunol. 2022. PMID: 35069563 Free PMC article.
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.
Beaudoin-Bussières G, Chen Y, Ullah I, Prévost J, Tolbert WD, Symmes K, Ding S, Benlarbi M, Gong SY, Tauzin A, Gasser R, Chatterjee D, Vézina D, Goyette G, Richard J, Zhou F, Stamatatos L, McGuire AT, Charest H, Roger M, Pozharski E, Kumar P, Mothes W, Uchil PD, Pazgier M, Finzi A. Beaudoin-Bussières G, et al. Among authors: chen y. Cell Rep. 2022 Feb 15;38(7):110368. doi: 10.1016/j.celrep.2022.110368. Epub 2022 Jan 25. Cell Rep. 2022. PMID: 35123652 Free PMC article.
VE607 Stabilizes SARS-CoV-2 Spike In the "RBD-up" Conformation and Inhibits Viral Entry.
Ding S, Gong SY, Grover J, Mohammadi M, Chen Y, Vézina D, Beaudoin-Bussières G, Verma VT, Goyette G, Richard J, Yang D, Smith AB, Pazgier M, Côté M, Abrams C, Mothes W, Finzi A, Baron C. Ding S, et al. Among authors: chen y. bioRxiv [Preprint]. 2022 Feb 22:2022.02.03.479007. doi: 10.1101/2022.02.03.479007. bioRxiv. 2022. Update in: iScience. 2022 Jul 15;25(7):104528. doi: 10.1016/j.isci.2022.104528 PMID: 35233570 Free PMC article. Updated. Preprint.
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