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Page 1
Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses.
Mittler E, Wec AZ, Tynell J, Guardado-Calvo P, Wigren-Byström J, Polanco LC, O'Brien CM, Slough MM, Abelson DM, Serris A, Sakharkar M, Pehau-Arnaudet G, Bakken RR, Geoghegan JC, Jangra RK, Keller M, Zeitlin L, Vapalahti O, Ulrich RG, Bornholdt ZA, Ahlm C, Rey FA, Dye JM, Bradfute SB, Strandin T, Herbert AS, Forsell MNE, Walker LM, Chandran K. Mittler E, et al. Among authors: tynell j. Sci Transl Med. 2022 Mar 16;14(636):eabl5399. doi: 10.1126/scitranslmed.abl5399. Epub 2022 Mar 16. Sci Transl Med. 2022. PMID: 35294259 Free PMC article.
Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody.
Mittler E, Serris A, Esterman ES, Florez C, Polanco LC, O'Brien CM, Slough MM, Tynell J, Gröning R, Sun Y, Abelson DM, Wec AZ, Haslwanter D, Keller M, Ye C, Bakken RR, Jangra RK, Dye JM, Ahlm C, Rappazzo CG, Ulrich RG, Zeitlin L, Geoghegan JC, Bradfute SB, Sidoli S, Forsell MNE, Strandin T, Rey FA, Herbert AS, Walker LM, Chandran K, Guardado-Calvo P. Mittler E, et al. Among authors: tynell j. Sci Transl Med. 2023 Jun 14;15(700):eadg1855. doi: 10.1126/scitranslmed.adg1855. Epub 2023 Jun 14. Sci Transl Med. 2023. PMID: 37315110
Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.
Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE. Kakkola L, et al. Among authors: tynell j. Cell Death Dis. 2013 Jul 25;4(7):e742. doi: 10.1038/cddis.2013.267. Cell Death Dis. 2013. PMID: 23887633 Free PMC article.
Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.
Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T, Kuivanen S, Vapalahti O, Kantele A, Tynell J, Julkunen I, Kallio-Kokko H, Paavilainen H, Hukkanen V, Elliott RM, De Brabander JK, Saelens X, Kainov DE. Denisova OV, et al. Among authors: tynell j. J Biol Chem. 2012 Oct 12;287(42):35324-35332. doi: 10.1074/jbc.M112.392142. Epub 2012 Aug 21. J Biol Chem. 2012. PMID: 22910914 Free PMC article.
Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.
Varnaitė R, García M, Glans H, Maleki KT, Sandberg JT, Tynell J, Christ W, Lagerqvist N, Asgeirsson H, Ljunggren HG, Ahlén G, Frelin L, Sällberg M, Blom K, Klingström J, Gredmark-Russ S. Varnaitė R, et al. Among authors: tynell j. J Immunol. 2020 Nov 1;205(9):2437-2446. doi: 10.4049/jimmunol.2000717. Epub 2020 Sep 2. J Immunol. 2020. PMID: 32878912 Free PMC article.
MAIT cell activation and dynamics associated with COVID-19 disease severity.
Parrot T, Gorin JB, Ponzetta A, Maleki KT, Kammann T, Emgård J, Perez-Potti A, Sekine T, Rivera-Ballesteros O; Karolinska COVID-19 Study Group; Gredmark-Russ S, Rooyackers O, Folkesson E, Eriksson LI, Norrby-Teglund A, Ljunggren HG, Björkström NK, Aleman S, Buggert M, Klingström J, Strålin K, Sandberg JK. Parrot T, et al. Sci Immunol. 2020 Sep 28;5(51):eabe1670. doi: 10.1126/sciimmunol.abe1670. Sci Immunol. 2020. PMID: 32989174 Free PMC article.
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.
Kvedaraite E, Hertwig L, Sinha I, Ponzetta A, Hed Myrberg I, Lourda M, Dzidic M, Akber M, Klingström J, Folkesson E, Muvva JR, Chen P, Gredmark-Russ S, Brighenti S, Norrby-Teglund A, Eriksson LI, Rooyackers O, Aleman S, Strålin K, Ljunggren HG, Ginhoux F, Björkström NK, Henter JI, Svensson M; Karolinska KI/K COVID-19 Study Group. Kvedaraite E, et al. Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018587118. doi: 10.1073/pnas.2018587118. Proc Natl Acad Sci U S A. 2021. PMID: 33479167 Free PMC article.
SARS-CoV-2-specific humoral and cellular immunity persists through 9 months irrespective of COVID-19 severity at hospitalisation.
Sandberg JT, Varnaitė R, Christ W, Chen P, Muvva JR, Maleki KT, García M, Dzidic M, Folkesson E, Skagerberg M, Ahlén G, Frelin L, Sällberg M, Eriksson LI, Rooyackers O, Sönnerborg A, Buggert M, Björkström NK, Aleman S, Strålin K, Klingström J, Ljunggren HG, Blom K, Gredmark-Russ S; Karolinska COVID‐19 Study Group. Sandberg JT, et al. Clin Transl Immunology. 2021 Jul 5;10(7):e1306. doi: 10.1002/cti2.1306. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34257967 Free PMC article.
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