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435 results

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Driver Mutation Variant Allele Frequency in Circulating Tumor DNA and Association with Clinical Outcome in Patients with Non-Small Cell Lung Cancer and EGFR- and KRAS-Mutated Tumors.
Li M, Yang L, Hughes J, van den Hout A, Burns C, Woodhouse R, Dennis L, Hegde P, Oxnard GR, Vietz C. Li M, et al. Among authors: hegde p. J Mol Diagn. 2022 May;24(5):543-553. doi: 10.1016/j.jmoldx.2022.02.002. Epub 2022 Mar 14. J Mol Diagn. 2022. PMID: 35301118 Free article.
Clinical and analytical validation of FoundationOne Liquid CDx, a novel 324-Gene cfDNA-based comprehensive genomic profiling assay for cancers of solid tumor origin.
Woodhouse R, Li M, Hughes J, Delfosse D, Skoletsky J, Ma P, Meng W, Dewal N, Milbury C, Clark T, Donahue A, Stover D, Kennedy M, Dacpano-Komansky J, Burns C, Vietz C, Alexander B, Hegde P, Dennis L. Woodhouse R, et al. Among authors: hegde p. PLoS One. 2020 Sep 25;15(9):e0237802. doi: 10.1371/journal.pone.0237802. eCollection 2020. PLoS One. 2020. PMID: 32976510 Free PMC article.
A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability and Pan-Tumor Characterization of 1000 Microsatellite Instability-High Cases in 67,000 Patient Samples.
Trabucco SE, Gowen K, Maund SL, Sanford E, Fabrizio DA, Hall MJ, Yakirevich E, Gregg JP, Stephens PJ, Frampton GM, Hegde PS, Miller VA, Ross JS, Hartmaier RJ, Huang SA, Sun JX. Trabucco SE, et al. Among authors: hegde ps. J Mol Diagn. 2019 Nov;21(6):1053-1066. doi: 10.1016/j.jmoldx.2019.06.011. Epub 2019 Aug 22. J Mol Diagn. 2019. PMID: 31445211 Free PMC article.
Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab.
Gandara DR, Paul SM, Kowanetz M, Schleifman E, Zou W, Li Y, Rittmeyer A, Fehrenbacher L, Otto G, Malboeuf C, Lieber DS, Lipson D, Silterra J, Amler L, Riehl T, Cummings CA, Hegde PS, Sandler A, Ballinger M, Fabrizio D, Mok T, Shames DS. Gandara DR, et al. Nat Med. 2018 Sep;24(9):1441-1448. doi: 10.1038/s41591-018-0134-3. Epub 2018 Aug 6. Nat Med. 2018. PMID: 30082870
Association of CD274 (PD-L1) Copy Number Changes with Immune Checkpoint Inhibitor Clinical Benefit in Non-Squamous Non-Small Cell Lung Cancer.
Murugesan K, Jin DX, Comment LA, Fabrizio D, Hegde PS, Elvin JA, Alexander B, Levy MA, Frampton GM, Montesion M, Roychowdhury S, Kurzrock R, Ross JS, Albacker LA, Huang RSP. Murugesan K, et al. Among authors: hegde ps. Oncologist. 2022 Sep 2;27(9):732-739. doi: 10.1093/oncolo/oyac096. Oncologist. 2022. PMID: 35598202 Free PMC article.
Somatic HLA Class I Loss Is a Widespread Mechanism of Immune Evasion Which Refines the Use of Tumor Mutational Burden as a Biomarker of Checkpoint Inhibitor Response.
Montesion M, Murugesan K, Jin DX, Sharaf R, Sanchez N, Guria A, Minker M, Li G, Fisher V, Sokol ES, Pavlick DC, Moore JA, Braly A, Singal G, Fabrizio D, Comment LA, Rizvi NA, Alexander BM, Frampton GM, Hegde PS, Albacker LA. Montesion M, et al. Cancer Discov. 2021 Feb;11(2):282-292. doi: 10.1158/2159-8290.CD-20-0672. Epub 2020 Oct 30. Cancer Discov. 2021. PMID: 33127846
Comprehensive Genomic Profiling (CGP)-Informed Personalized Molecular Residual Disease (MRD) Detection: An Exploratory Analysis from the PREDATOR Study of Metastatic Colorectal Cancer (mCRC) Patients Undergoing Surgical Resection.
Lonardi S, Nimeiri H, Xu C, Zollinger DR, Madison RW, Fine AD, Gjoerup O, Rasola C, Angerilli V, Sharma S, Wu HT, Palsuledesai CC, Malhotra M, Aleshin A, Loupakis F, Renkonen E, Hegde P, Fassan M. Lonardi S, et al. Among authors: hegde p. Int J Mol Sci. 2022 Sep 29;23(19):11529. doi: 10.3390/ijms231911529. Int J Mol Sci. 2022. PMID: 36232827 Free PMC article.
Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer.
Coffey DG, Xu Y, Towlerton AMH, Kowanetz M, Hegde P, Darwish M, Yadav M, Blanchette C, Ruppert SM, Bertino S, Xu Q, Ferretti A, Weinheimer A, Hellmann M, Qin A, Thomas D, Warren EH, Ramnath N. Coffey DG, et al. Among authors: hegde p. Front Immunol. 2022 Sep 9;13:961105. doi: 10.3389/fimmu.2022.961105. eCollection 2022. Front Immunol. 2022. PMID: 36159875 Free PMC article.
435 results