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S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy.
Li J, Shu X, Xu J, Su SM, Chan UI, Mo L, Liu J, Zhang X, Adhav R, Chen Q, Wang Y, An T, Zhang X, Lyu X, Li X, Lei JH, Miao K, Sun H, Xing F, Zhang A, Deng C, Xu X. Li J, et al. Among authors: an t. Nat Commun. 2022 Mar 18;13(1):1481. doi: 10.1038/s41467-022-29151-5. Nat Commun. 2022. PMID: 35304461 Free PMC article.
[Therapeutic efficacy analysis of immunotherapy in small cell lung cancer].
Zhong J, Zheng QW, Zhao J, Wang ZP, Wu MN, Zhuo ML, Wang YY, Li JJ, Yang X, Chen HX, An TT. Zhong J, et al. Among authors: an tt. Zhonghua Zhong Liu Za Zhi. 2020 Sep 23;42(9):771-776. doi: 10.3760/cma.j.cn112152-20200324-00253. Zhonghua Zhong Liu Za Zhi. 2020. PMID: 32988161 Chinese.
[Progress in treatment for malignant pleural mesothelioma].
Wang YY, He YL, Chi YJ, Zhai XY, An TT, Li JJ, Zhuo ML, Zhao J, Wang ZP. Wang YY, et al. Among authors: an tt. Zhonghua Jie He He Hu Xi Za Zhi. 2022 Jan 12;45(1):111-115. doi: 10.3760/cma.j.cn112147-20210413-00245. Zhonghua Jie He He Hu Xi Za Zhi. 2022. PMID: 35000316 Review. Chinese.
ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine.
Xu J, Su SM, Zhang X, Chan UI, Adhav R, Shu X, Liu J, Li J, Mo L, Wang Y, An T, Lei JH, Miao K, Deng CX, Xu X. Xu J, et al. Among authors: an t. J Clin Invest. 2022 Mar 1;132(5):e149473. doi: 10.1172/JCI149473. J Clin Invest. 2022. PMID: 35025764 Free PMC article.
Further analysis revealed that cells with low ATP11B expression and high PTDSS2 expression (ATP11BloPTDSS2hi cells) were associated with poor prognosis and enhanced metastasis in breast cancer patients in general. Mechanistically, an ATP11BloPTDSS2hi phenotype was associat …
Further analysis revealed that cells with low ATP11B expression and high PTDSS2 expression (ATP11BloPTDSS2hi cells) were associated with poo …
BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance.
Shu X, Li J, Chan UI, Su SM, Shi C, Zhang X, An T, Xu J, Mo L, Liu J, Wang Y, Li X, Deng M, Lei JH, Wang C, Tian H, Heng S, Shim JS, Zhang X, Dai Y, Yao Z, Kuang X, Lin Y, Deng CX, Xu X. Shu X, et al. Among authors: an t. Cancer Res. 2023 Aug 1;83(15):2614-2633. doi: 10.1158/0008-5472.CAN-22-3398. Cancer Res. 2023. PMID: 37227919 Free PMC article.
Cancer metastasis is an extremely complex process affected by many factors. An acidic microenvironment can drive cancer cell migration toward blood vessels while also hampering immune cell activity. Here, we identified a mechanism mediated by sialyltransferases that …
Cancer metastasis is an extremely complex process affected by many factors. An acidic microenvironment can drive cancer cell m …
1,469 results