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PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors.
Ferdosi SR, Taylor B, Lee M, Tang N, Peng S, Bybee R, Reid G, Hartman L, Garcia-Mansfield K, Sharma R, Pirrotte P, Ma J, Parisian AD, Furnari F, Dhruv HD, Berens ME. Ferdosi SR, et al. Among authors: sharma r. Neuro Oncol. 2022 Nov 2;24(11):1857-1868. doi: 10.1093/neuonc/noac067. Neuro Oncol. 2022. Retraction in: Neuro Oncol. 2024 Apr 5;26(4):775. doi: 10.1093/neuonc/noad081 PMID: 35305088 Free PMC article. Retracted.
Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition.
Lang JD, Hendricks WPD, Orlando KA, Yin H, Kiefer J, Ramos P, Sharma R, Pirrotte P, Raupach EA, Sereduk C, Tang N, Liang WS, Washington M, Facista SJ, Zismann VL, Cousins EM, Major MB, Wang Y, Karnezis AN, Sekulic A, Hass R, Vanderhyden BC, Nair P, Weissman BE, Huntsman DG, Trent JM. Lang JD, et al. Among authors: sharma r. Clin Cancer Res. 2018 Apr 15;24(8):1932-1943. doi: 10.1158/1078-0432.CCR-17-1928. Epub 2018 Feb 9. Clin Cancer Res. 2018. PMID: 29440177 Free PMC article.
A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells.
Castanotto D, Zhang X, Rüger J, Alluin J, Sharma R, Pirrotte P, Joenson L, Ioannou S, Nelson MS, Vikeså J, Hansen BR, Koch T, Jensen MA, Rossi JJ, Stein CA. Castanotto D, et al. Among authors: sharma r. Mol Ther Nucleic Acids. 2020 Oct 27;23:63-75. doi: 10.1016/j.omtn.2020.10.032. eCollection 2021 Mar 5. Mol Ther Nucleic Acids. 2020. PMID: 33335793 Free PMC article.
Defining the Caprin-1 Interactome in Unstressed and Stressed Conditions.
Vu L, Ghosh A, Tran C, Tebung WA, Sidibé H, Garcia-Mansfield K, David-Dirgo V, Sharma R, Pirrotte P, Bowser R, Vande Velde C. Vu L, et al. Among authors: sharma r. J Proteome Res. 2021 Jun 4;20(6):3165-3178. doi: 10.1021/acs.jproteome.1c00016. Epub 2021 May 3. J Proteome Res. 2021. PMID: 33939924 Free PMC article.
EGFRvIII Confers Sensitivity to Saracatinib in a STAT5-Dependent Manner in Glioblastoma.
Blomquist MR, Eghlimi R, Beniwal A, Grief D, Nascari DG, Inge L, Sereduk CP, Tuncali S, Roos A, Inforzato H, Sharma R, Pirrotte P, Mehta S, Fortin Ensign SP, Loftus JC, Tran NL. Blomquist MR, et al. Among authors: sharma r. Int J Mol Sci. 2024 Jun 6;25(11):6279. doi: 10.3390/ijms25116279. Int J Mol Sci. 2024. PMID: 38892466 Free PMC article.
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