Chandel NS - Search Results

1

Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.

Guan N, Kobayashi H, Ishii K, Davidoff O, Sha F, Ikizler TA, Hao CM, Chandel NS, Haase VH. Guan N, et al. Among authors: chandel ns. Kidney Int. 2022 Jul;102(1):108-120. doi: 10.1016/j.kint.2022.02.030. Epub 2022 Mar 24. Kidney Int. 2022. PMID: 35341793 Free PMC article.

2

Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.

Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH. Ishii K, et al. Among authors: chandel ns. Kidney Int. 2021 Mar;99(3):657-670. doi: 10.1016/j.kint.2020.10.013. Epub 2020 Nov 4. Kidney Int. 2021. PMID: 33159962 Free PMC article.

3

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.

Brunelle JK, Bell EL, Quesada NM, Vercauteren K, Tiranti V, Zeviani M, Scarpulla RC, Chandel NS. Brunelle JK, et al. Among authors: chandel ns. Cell Metab. 2005 Jun;1(6):409-14. doi: 10.1016/j.cmet.2005.05.002. Cell Metab. 2005. PMID: 16054090 Free article.

4

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production.

Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, Chandel NS. Bell EL, et al. Among authors: chandel ns. J Cell Biol. 2007 Jun 18;177(6):1029-36. doi: 10.1083/jcb.200609074. Epub 2007 Jun 11. J Cell Biol. 2007. PMID: 17562787 Free PMC article.

5

Genetics of mitochondrial electron transport chain in regulating oxygen sensing.

Bell EL, Chandel NS. Bell EL, et al. Among authors: chandel ns. Methods Enzymol. 2007;435:447-61. doi: 10.1016/S0076-6879(07)35023-4. Methods Enzymol. 2007. PMID: 17998068

6

Mitochondrial complex III regulates hypoxic activation of HIF.

Klimova T, Chandel NS. Klimova T, et al. Among authors: chandel ns. Cell Death Differ. 2008 Apr;15(4):660-6. doi: 10.1038/sj.cdd.4402307. Epub 2008 Jan 25. Cell Death Differ. 2008. PMID: 18219320 Review.

7

Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution.

Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR. Soberanes S, et al. Among authors: chandel ns. J Biol Chem. 2009 Jan 23;284(4):2176-86. doi: 10.1074/jbc.M808844200. Epub 2008 Nov 25. J Biol Chem. 2009. PMID: 19033436 Free PMC article.

8

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.

Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS. Emerling BM, et al. Among authors: chandel ns. Free Radic Biol Med. 2009 May 15;46(10):1386-91. doi: 10.1016/j.freeradbiomed.2009.02.019. Epub 2009 Mar 3. Free Radic Biol Med. 2009. PMID: 19268526 Free PMC article.

9

Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS. Sena LA, et al. Among authors: chandel ns. Immunity. 2013 Feb 21;38(2):225-36. doi: 10.1016/j.immuni.2012.10.020. Epub 2013 Feb 15. Immunity. 2013. PMID: 23415911 Free PMC article.

10

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.

Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Wheaton WW, et al. Among authors: chandel ns. Elife. 2014 May 13;3:e02242. doi: 10.7554/eLife.02242. Elife. 2014. PMID: 24843020 Free PMC article.

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