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In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.
De Keersmaecker K, Lahortiga I, Mentens N, Folens C, Van Neste L, Bekaert S, Vandenberghe P, Odero MD, Marynen P, Cools J. De Keersmaecker K, et al. Among authors: mentens n. Haematologica. 2008 Apr;93(4):533-42. doi: 10.3324/haematol.11894. Epub 2008 Mar 5. Haematologica. 2008. PMID: 18322257 Free article.
NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins.
De Keersmaecker K, Porcu M, Cox L, Girardi T, Vandepoel R, de Beeck JO, Gielen O, Mentens N, Bennett KL, Hantschel O. De Keersmaecker K, et al. Among authors: mentens n. Haematologica. 2014 Jan;99(1):85-93. doi: 10.3324/haematol.2013.088674. Epub 2013 Jul 19. Haematologica. 2014. PMID: 23872305 Free PMC article.
Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia.
Vanden Bempt M, Demeyer S, Broux M, De Bie J, Bornschein S, Mentens N, Vandepoel R, Geerdens E, Radaelli E, Bornhauser BC, Kulozik AE, Meijerink JP, Bourquin JP, de Bock CE, Cools J. Vanden Bempt M, et al. Among authors: mentens n. Cancer Cell. 2018 Aug 13;34(2):271-285.e7. doi: 10.1016/j.ccell.2018.07.007. Cancer Cell. 2018. PMID: 30107177 Free PMC article.
The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia.
Verbeke D, Demeyer S, Prieto C, de Bock CE, De Bie J, Gielen O, Jacobs K, Mentens N, Verhoeven BM, Uyttebroeck A, Boeckx N, De Keersmaecker K, Maertens J, Segers H, Cools J. Verbeke D, et al. Among authors: mentens n. Clin Cancer Res. 2020 Nov 1;26(21):5747-5758. doi: 10.1158/1078-0432.CCR-20-1315. Epub 2020 Aug 21. Clin Cancer Res. 2020. PMID: 32826328
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
Lahortiga I, De Keersmaecker K, Van Vlierberghe P, Graux C, Cauwelier B, Lambert F, Mentens N, Beverloo HB, Pieters R, Speleman F, Odero MD, Bauters M, Froyen G, Marynen P, Vandenberghe P, Wlodarska I, Meijerink JP, Cools J. Lahortiga I, et al. Among authors: mentens n. Nat Genet. 2007 May;39(5):593-5. doi: 10.1038/ng2025. Epub 2007 Apr 15. Nat Genet. 2007. PMID: 17435759
33 results