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Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes.
Houtman E, Tuerlings M, Suchiman HED, Lakenberg N, Cornelis FMF, Mei H, Broekhuis D, Nelissen RGHH, Coutinho de Almeida R, Ramos YFM, Lories RJ, Cruz LJ, Meulenbelt I. Houtman E, et al. Among authors: ramos yfm. Rheumatology (Oxford). 2022 Dec 23;62(1):457-466. doi: 10.1093/rheumatology/keac202. Rheumatology (Oxford). 2022. PMID: 35383365 Free PMC article.
Genes expressed in blood link osteoarthritis with apoptotic pathways.
Ramos YF, Bos SD, Lakenberg N, Böhringer S, den Hollander WJ, Kloppenburg M, Slagboom PE, Meulenbelt I. Ramos YF, et al. Ann Rheum Dis. 2014 Oct;73(10):1844-53. doi: 10.1136/annrheumdis-2013-203405. Epub 2013 Jul 17. Ann Rheum Dis. 2014. PMID: 23864235
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis.
Bomer N, den Hollander W, Ramos YF, Bos SD, van der Breggen R, Lakenberg N, Pepers BA, van Eeden AE, Darvishan A, Tobi EW, Duijnisveld BJ, van den Akker EB, Heijmans BT, van Roon-Mom WM, Verbeek FJ, van Osch GJ, Nelissen RG, Slagboom PE, Meulenbelt I. Bomer N, et al. Ann Rheum Dis. 2015 Aug;74(8):1571-9. doi: 10.1136/annrheumdis-2013-204739. Epub 2014 Apr 2. Ann Rheum Dis. 2015. PMID: 24695009 Free PMC article.
The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.
Bomer N, Cornelis FM, Ramos YF, den Hollander W, Storms L, van der Breggen R, Lakenberg N, Slagboom PE, Meulenbelt I, Lories RJ. Bomer N, et al. Ann Rheum Dis. 2016 Mar;75(3):571-7. doi: 10.1136/annrheumdis-2014-206608. Epub 2014 Dec 30. Ann Rheum Dis. 2016. PMID: 25550340
73 results