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The design, synthesis, and in vitro trypanocidal and leishmanicidal activities of 1,3-thiazole and 4-thiazolidinone ester derivatives.
Haroon M, de Barros Dias MCH, Santos ACDS, Pereira VRA, Barros Freitas LA, Balbinot RB, Kaplum V, Nakamura CV, Alves LC, Brayner FA, Leite ACL, Akhtar T. Haroon M, et al. Among authors: leite acl. RSC Adv. 2021 Jan 11;11(4):2487-2500. doi: 10.1039/d0ra06994a. eCollection 2021 Jan 6. RSC Adv. 2021. PMID: 35424158 Free PMC article.
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Moreira DR, Costa SP, Hernandes MZ, Rabello MM, de Oliveira Filho GB, de Melo CM, da Rocha LF, de Simone CA, Ferreira RS, Fradico JR, Meira CS, Guimarães ET, Srivastava RM, Pereira VR, Soares MB, Leite AC. Moreira DR, et al. J Med Chem. 2012 Dec 27;55(24):10918-36. doi: 10.1021/jm301518v. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23167554
Sulfonamide-metal complexes endowed with potent anti-Trypanosoma cruzi activity.
Chohan ZH, Hernandes MZ, Sensato FR, Moreira DR, Pereira VR, Neves JK, de Oliveira AP, de Oliveira BC, Leite AC. Chohan ZH, et al. J Enzyme Inhib Med Chem. 2014 Apr;29(2):230-6. doi: 10.3109/14756366.2013.766608. Epub 2013 Feb 25. J Enzyme Inhib Med Chem. 2014. PMID: 23432595 Free article.
Evaluation of the anti-Schistosoma mansoni activity of thiosemicarbazones and thiazoles.
Santiago Ede F, de Oliveira SA, de Oliveira Filho GB, Moreira DR, Gomes PA, da Silva AL, de Barros AF, da Silva AC, Dos Santos TA, Pereira VR, Gonçalves GG, Brayner FA, Alves LC, Wanderley AG, Leite AC. Santiago Ede F, et al. Antimicrob Agents Chemother. 2014;58(1):352-63. doi: 10.1128/AAC.01900-13. Epub 2013 Oct 28. Antimicrob Agents Chemother. 2014. PMID: 24165185 Free PMC article.
Conformational restriction of aryl thiosemicarbazones produces potent and selective anti-Trypanosoma cruzi compounds which induce apoptotic parasite death.
Magalhaes Moreira DR, de Oliveira AD, Teixeira de Moraes Gomes PA, de Simone CA, Villela FS, Ferreira RS, da Silva AC, dos Santos TA, Brelaz de Castro MC, Pereira VR, Leite AC. Magalhaes Moreira DR, et al. Eur J Med Chem. 2014 Mar 21;75:467-78. doi: 10.1016/j.ejmech.2014.02.001. Epub 2014 Feb 3. Eur J Med Chem. 2014. PMID: 24561675
Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Espíndola JW, Cardoso MV, Filho GB, Oliveira E Silva DA, Moreira DR, Bastos TM, Simone CA, Soares MB, Villela FS, Ferreira RS, Castro MC, Pereira VR, Murta SM, Sales Junior PA, Romanha AJ, Leite AC. Espíndola JW, et al. Eur J Med Chem. 2015 Aug 28;101:818-35. doi: 10.1016/j.ejmech.2015.06.048. Epub 2015 Jul 3. Eur J Med Chem. 2015. PMID: 26231082
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