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Page 1
Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.
Blume T, Deussing M, Biechele G, Peters F, Zott B, Schmidt C, Franzmeier N, Wind K, Eckenweber F, Sacher C, Shi Y, Ochs K, Kleinberger G, Xiang X, Focke C, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Baumann K, Adelsberger H, Rominger A, Cumming P, Willem M, Dorostkar MM, Herms J, Brendel M. Blume T, et al. Among authors: willem m. Front Aging Neurosci. 2022 Mar 30;14:854031. doi: 10.3389/fnagi.2022.854031. eCollection 2022. Front Aging Neurosci. 2022. PMID: 35431893 Free PMC article.
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C. Capell A, et al. Among authors: willem m. J Neurosci. 2011 Feb 2;31(5):1885-94. doi: 10.1523/JNEUROSCI.5757-10.2011. J Neurosci. 2011. PMID: 21289198 Free PMC article.
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, Tahirovic S, Herms J, Willem M, Pettkus N, Butovsky O, Bartenstein P, Edbauer D, Rominger A, Ertürk A, Grathwohl SA, Neher JJ, Holtzman DM, Meyer-Luehmann M, Haass C. Parhizkar S, et al. Among authors: willem m. Nat Neurosci. 2019 Feb;22(2):191-204. doi: 10.1038/s41593-018-0296-9. Epub 2019 Jan 7. Nat Neurosci. 2019. PMID: 30617257 Free PMC article.
Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects.
Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J. Vöglein J, et al. Among authors: willem m. Neurobiol Aging. 2019 Dec;84:241.e5-241.e11. doi: 10.1016/j.neurobiolaging.2019.08.034. Epub 2019 Sep 20. Neurobiol Aging. 2019. PMID: 31627977
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, Tahirovic S, Park JI, Prorok R, Mahon C, Liang CC, Shi J, Kim DJ, Sabelström H, Huang F, Di Paolo G, Simons M, Lewcock JW, Haass C. Schlepckow K, et al. Among authors: willem m. EMBO Mol Med. 2020 Apr 7;12(4):e11227. doi: 10.15252/emmm.201911227. Epub 2020 Mar 10. EMBO Mol Med. 2020. PMID: 32154671 Free PMC article.
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.
Sacher C, Blume T, Beyer L, Biechele G, Sauerbeck J, Eckenweber F, Deussing M, Focke C, Parhizkar S, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Baumann K, Tahirovic S, Kleinberger G, Willem M, Haass C, Bartenstein P, Cumming P, Rominger A, Herms J, Brendel M. Sacher C, et al. Among authors: willem m. J Nucl Med. 2020 Dec;61(12):1825-1831. doi: 10.2967/jnumed.120.242750. Epub 2020 May 15. J Nucl Med. 2020. PMID: 32414948 Free article.
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.
Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, Lichtenthaler SF, Tahirovic S. Sebastian Monasor L, et al. Among authors: willem m. Elife. 2020 Jun 8;9:e54083. doi: 10.7554/eLife.54083. Elife. 2020. PMID: 32510331 Free PMC article.
Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice.
Biechele G, Wind K, Blume T, Sacher C, Beyer L, Eckenweber F, Franzmeier N, Ewers M, Zott B, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Tahirovic S, Willem M, Bartenstein P, Cumming P, Rominger A, Herms J, Brendel M. Biechele G, et al. Among authors: willem m. Neuroimage. 2021 Apr 15;230:117707. doi: 10.1016/j.neuroimage.2020.117707. Epub 2020 Dec 29. Neuroimage. 2021. PMID: 33385560 Free article.
Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease.
Biechele G, Monasor LS, Wind K, Blume T, Parhizkar S, Arzberger T, Sacher C, Beyer L, Eckenweber F, Gildehaus FJ, von Ungern-Sternberg B, Willem M, Bartenstein P, Cumming P, Rominger A, Herms J, Lichtenthaler SF, Haass C, Tahirovic S, Brendel M. Biechele G, et al. Among authors: willem m. J Nucl Med. 2022 Jan;63(1):117-124. doi: 10.2967/jnumed.120.261858. Epub 2021 May 20. J Nucl Med. 2022. PMID: 34016733 Free PMC article.
80 results