Frkic R - Search Results

1

Antiviral cyclic peptides targeting the main protease of SARS-CoV-2.

Johansen-Leete J, Ullrich S, Fry SE, Frkic R, Bedding MJ, Aggarwal A, Ashhurst AS, Ekanayake KB, Mahawaththa MC, Sasi VM, Luedtke S, Ford DJ, O'Donoghue AJ, Passioura T, Larance M, Otting G, Turville S, Jackson CJ, Nitsche C, Payne RJ. Johansen-Leete J, et al. Among authors: frkic r. Chem Sci. 2022 Feb 28;13(13):3826-3836. doi: 10.1039/d1sc06750h. eCollection 2022 Mar 30. Chem Sci. 2022. PMID: 35432913 Free PMC article.

2

Through-Space Scalar ¹⁹F-¹⁹F Couplings between Fluorinated Noncanonical Amino Acids for the Detection of Specific Contacts in Proteins.

Orton HW, Qianzhu H, Abdelkader EH, Habel EI, Tan YJ, Frkic RL, Jackson CJ, Huber T, Otting G. Orton HW, et al. J Am Chem Soc. 2021 Nov 24;143(46):19587-19598. doi: 10.1021/jacs.1c10104. Epub 2021 Nov 15. J Am Chem Soc. 2021. PMID: 34780162

3

Genetic Encoding of Cyanopyridylalanine for In-Cell Protein Macrocyclization by the Nitrile-Aminothiol Click Reaction.

Abdelkader EH, Qianzhu H, George J, Frkic RL, Jackson CJ, Nitsche C, Otting G, Huber T. Abdelkader EH, et al. Among authors: frkic rl. Angew Chem Int Ed Engl. 2022 Mar 21;61(13):e202114154. doi: 10.1002/anie.202114154. Epub 2022 Feb 11. Angew Chem Int Ed Engl. 2022. PMID: 35102680 Free PMC article.

4

PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles.

Frkic RL, Pederick JL, Horsfall AJ, Jovcevski B, Crame EE, Kowalczyk W, Pukala TL, Chang MR, Zheng J, Blayo AL, Abell AD, Kamenecka TM, Harbort JS, Harmer JR, Griffin PR, Bruning JB. Frkic RL, et al. ACS Chem Biol. 2023 May 19;18(5):1115-1123. doi: 10.1021/acschembio.2c00917. Epub 2023 May 5. ACS Chem Biol. 2023. PMID: 37146157

5

Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.

Elzahhar PA, Alaaeddine R, Ibrahim TM, Nassra R, Ismail A, Chua BSK, Frkic RL, Bruning JB, Wallner N, Knape T, von Knethen A, Labib H, El-Yazbi AF, Belal ASF. Elzahhar PA, et al. Among authors: frkic rl. Eur J Med Chem. 2019 Apr 1;167:562-582. doi: 10.1016/j.ejmech.2019.02.034. Epub 2019 Feb 13. Eur J Med Chem. 2019. PMID: 30818268

6

Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics.

Frkic RL, He Y, Rodriguez BB, Chang MR, Kuruvilla D, Ciesla A, Abell AD, Kamenecka TM, Griffin PR, Bruning JB. Frkic RL, et al. J Med Chem. 2017 Jun 8;60(11):4584-4593. doi: 10.1021/acs.jmedchem.6b01727. Epub 2017 May 22. J Med Chem. 2017. PMID: 28485590 Free PMC article.

7

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.

Frkic RL, Marshall AC, Blayo AL, Pukala TL, Kamenecka TM, Griffin PR, Bruning JB. Frkic RL, et al. iScience. 2018 Feb 27;5:69-79. doi: 10.1016/j.isci.2018.06.012. Epub 2018 Jul 2. iScience. 2018. PMID: 30123887 Free PMC article.

8

Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways.

Chang MR, Ciesla A, Strutzenberg TS, Novick SJ, He Y, Garcia-Ordonez RD, Frkic RL, Bruning JB, Kamenecka TM, Griffin PR. Chang MR, et al. Among authors: frkic rl. ACS Chem Biol. 2019 May 17;14(5):1051-1062. doi: 10.1021/acschembio.9b00236. Epub 2019 Apr 15. ACS Chem Biol. 2019. PMID: 30951276

9

Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988.

Frkic RL, Chua BS, Shin Y, Pascal BD, Novick SJ, Kamenecka TM, Griffin PR, Bruning JB. Frkic RL, et al. Nucl Receptor Res. 2018;5:101350. doi: 10.11131/2018/101350. Nucl Receptor Res. 2018. PMID: 30906767 Free PMC article.

10

Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules.

Frkic RL, Bruning JB. Frkic RL, et al. Methods Mol Biol. 2019;1966:253-260. doi: 10.1007/978-1-4939-9195-2_21. Methods Mol Biol. 2019. PMID: 31041754

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