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Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade.
Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, Feng L, Gordon DJ, Zhang J, Pirrotte P, Chen CW, Salhotra A, Kuo YH, Horne D, Marcucci G, Sykes DB, Tiziani S, Jin H, Wang X, Li L. Wang H, et al. Among authors: lu x. Blood. 2022 Jun 30;139(26):3752-3770. doi: 10.1182/blood.2021015108. Blood. 2022. PMID: 35439288 Free PMC article.
Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Lu WC, Saha A, Yan W, Garrison K, Lamb C, Pandey R, Irani S, Lodi A, Lu X, Tiziani S, Zhang YJ, Georgiou G, DiGiovanni J, Stone E. Lu WC, et al. Among authors: lu x. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):13000-13011. doi: 10.1073/pnas.1917362117. Epub 2020 May 20. Proc Natl Acad Sci U S A. 2020. PMID: 32434918 Free PMC article.
Gilteritinib Inhibits Glutamine Uptake and Utilization in FLT3-ITD-Positive AML.
Zavorka Thomas ME, Lu X, Talebi Z, Jeon JY, Buelow DR, Gibson AA, Uddin ME, Brinton LT, Nguyen J, Collins M, Lodi A, Sweeney SR, Campbell MJ, Sweet DH, Sparreboom A, Lapalombella R, Tiziani S, Baker SD. Zavorka Thomas ME, et al. Among authors: lu x. Mol Cancer Ther. 2021 Nov;20(11):2207-2217. doi: 10.1158/1535-7163.MCT-21-0071. Epub 2021 Sep 13. Mol Cancer Ther. 2021. PMID: 34518298 Free PMC article.
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