Lei G - Search Results

1

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers.

Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, Shi J, Liu X, Horbath A, Das M, Li W, Poyurovsky MV, Olszewski K, Gan B. Koppula P, et al. Among authors: lei g. Nat Commun. 2022 Apr 22;13(1):2206. doi: 10.1038/s41467-022-29905-1. Nat Commun. 2022. PMID: 35459868 Free PMC article.

2

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression.

Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, Ajani JA, Xiao Q, Liao Z, Wang H, Gan B. Lei G, et al. Cell Res. 2020 Feb;30(2):146-162. doi: 10.1038/s41422-019-0263-3. Epub 2020 Jan 16. Cell Res. 2020. PMID: 31949285 Free PMC article.

3

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, Zhang J, Lee H, Koppula P, Lei G, Zhuang L, You MJ, Fang B, Li W, Metallo CM, Poyurovsky MV, Gan B. Liu X, et al. Among authors: lei g. Nat Cell Biol. 2020 Apr;22(4):476-486. doi: 10.1038/s41556-020-0496-x. Epub 2020 Mar 30. Nat Cell Biol. 2020. PMID: 32231310 Free PMC article.

4

H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death.

Zhang Y, Shi J, Liu X, Xiao Z, Lei G, Lee H, Koppula P, Cheng W, Mao C, Zhuang L, Ma L, Li W, Gan B. Zhang Y, et al. Among authors: lei g. Cancer Res. 2020 Jun 1;80(11):2243-2256. doi: 10.1158/0008-5472.CAN-19-3580. Epub 2020 Apr 9. Cancer Res. 2020. PMID: 32273282 Free PMC article.

5

Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma.

Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Song S, et al. Among authors: lei g. Gut. 2021 Dec;70(12):2238-2248. doi: 10.1136/gutjnl-2020-321175. Epub 2021 Jan 24. Gut. 2021. PMID: 33487592 Free PMC article. Clinical Trial.

6

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation.

Zhang Y, Swanda RV, Nie L, Liu X, Wang C, Lee H, Lei G, Mao C, Koppula P, Cheng W, Zhang J, Xiao Z, Zhuang L, Fang B, Chen J, Qian SB, Gan B. Zhang Y, et al. Among authors: lei g. Nat Commun. 2021 Mar 11;12(1):1589. doi: 10.1038/s41467-021-21841-w. Nat Commun. 2021. PMID: 33707434 Free PMC article.

7

PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer.

Hong T, Lei G, Chen X, Li H, Zhang X, Wu N, Zhao Y, Zhang Y, Wang J. Hong T, et al. Among authors: lei g. Redox Biol. 2021 Jun;42:101928. doi: 10.1016/j.redox.2021.101928. Epub 2021 Mar 5. Redox Biol. 2021. PMID: 33722571 Free PMC article.

8

Ferroptosis, radiotherapy, and combination therapeutic strategies.

Lei G, Mao C, Yan Y, Zhuang L, Gan B. Lei G, et al. Protein Cell. 2021 Nov;12(11):836-857. doi: 10.1007/s13238-021-00841-y. Epub 2021 Apr 23. Protein Cell. 2021. PMID: 33891303 Free PMC article. Review.

9

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity.

Lei G, Zhang Y, Hong T, Zhang X, Liu X, Mao C, Yan Y, Koppula P, Cheng W, Sood AK, Liu J, Gan B. Lei G, et al. Oncogene. 2021 May;40(20):3533-3547. doi: 10.1038/s41388-021-01790-w. Epub 2021 Apr 29. Oncogene. 2021. PMID: 33927351 Free PMC article.

10

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.

Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Mao C, et al. Among authors: lei g. Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. Nature. 2021. PMID: 33981038 Free PMC article.

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