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Page 1
Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity.
Gross AM, Glassberg B, Wolters PL, Dombi E, Baldwin A, Fisher MJ, Kim A, Bornhorst M, Weiss BD, Blakeley JO, Whitcomb P, Paul SM, Steinberg SM, Venzon DJ, Martin S, Carbonell A, Heisey K, Therrien J, Kapustina O, Dufek A, Derdak J, Smith MA, Widemann BC. Gross AM, et al. Among authors: derdak j. Neuro Oncol. 2022 Nov 2;24(11):1978-1988. doi: 10.1093/neuonc/noac109. Neuro Oncol. 2022. PMID: 35467749 Free PMC article. Clinical Trial.
Metabolic syndrome traits in long-term survivors of pediatric sarcoma.
Hoffman KE, Derdak J, Bernstein D, Reynolds JC, Avila NA, Gerber L, Steinberg SM, Chrousos G, Mackall CL, Mansky PJ. Hoffman KE, et al. Among authors: derdak j. Pediatr Blood Cancer. 2008 Feb;50(2):341-6. doi: 10.1002/pbc.21363. Pediatr Blood Cancer. 2008. PMID: 17918262
18-fluorodeoxyglucose-positron emission tomography (FDG-PET) evaluation of nodular lesions in patients with Neurofibromatosis type 1 and plexiform neurofibromas (PN) or malignant peripheral nerve sheath tumors (MPNST).
Meany H, Dombi E, Reynolds J, Whatley M, Kurwa A, Tsokos M, Salzer W, Gillespie A, Baldwin A, Derdak J, Widemann B. Meany H, et al. Among authors: derdak j. Pediatr Blood Cancer. 2013 Jan;60(1):59-64. doi: 10.1002/pbc.24212. Epub 2012 May 29. Pediatr Blood Cancer. 2013. PMID: 22645095 Free PMC article.
A Phase II Trial of Vandetanib in Children and Adults with Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor.
Glod J, Arnaldez FI, Wiener L, Spencer M, Killian JK, Meltzer P, Dombi E, Derse-Anthony C, Derdak J, Srinivasan R, Linehan WM, Miettinen M, Steinberg SM, Helman L, Widemann BC. Glod J, et al. Among authors: derdak j. Clin Cancer Res. 2019 Nov 1;25(21):6302-6308. doi: 10.1158/1078-0432.CCR-19-0986. Epub 2019 Aug 22. Clin Cancer Res. 2019. PMID: 31439578 Free PMC article. Clinical Trial.
Cediranib phase-II study in children with metastatic alveolar soft-part sarcoma (ASPS).
Cohen JW, Widemann BC, Derdak J, Dombi E, Goodwin A, Dompierre J, Onukwubiri U, Steinberg SM, O'Sullivan Coyne G, Kummar S, Chen AP, Glod J. Cohen JW, et al. Among authors: derdak j. Pediatr Blood Cancer. 2019 Dec;66(12):e27987. doi: 10.1002/pbc.27987. Epub 2019 Sep 10. Pediatr Blood Cancer. 2019. PMID: 31502400 Free PMC article. Clinical Trial.
The MEK inhibitor selumetinib reduces spinal neurofibroma burden in patients with NF1 and plexiform neurofibromas.
Jackson S, Baker EH, Gross AM, Whitcomb P, Baldwin A, Derdak J, Tibery C, Desanto J, Carbonell A, Yohay K, O'Sullivan G, Chen AP, Widemann BC, Dombi E. Jackson S, et al. Among authors: derdak j. Neurooncol Adv. 2020 Aug 8;2(1):vdaa095. doi: 10.1093/noajnl/vdaa095. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 32939452 Free PMC article.
Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I-Related Plexiform Neurofibromas.
Boal LH, Glod J, Spencer M, Kasai M, Derdak J, Dombi E, Ahlman M, Beury DW, Merchant MS, Persenaire C, Liewehr DJ, Steinberg SM, Widemann BC, Kaplan RN. Boal LH, et al. Among authors: derdak j. Clin Cancer Res. 2020 Dec 1;26(23):6112-6121. doi: 10.1158/1078-0432.CCR-20-1696. Epub 2020 Sep 17. Clin Cancer Res. 2020. PMID: 32943455 Free PMC article. Clinical Trial.
Long-term safety and efficacy of selumetinib in children with neurofibromatosis type 1 on a phase 1/2 trial for inoperable plexiform neurofibromas.
Gross AM, Dombi E, Wolters PL, Baldwin A, Dufek A, Herrera K, Martin S, Derdak J, Heisey KS, Whitcomb PM, Steinberg SM, Venzon DJ, Fisher MJ, Kim A, Bornhorst M, Weiss BD, Blakeley JO, Smith MA, Widemann BC. Gross AM, et al. Among authors: derdak j. Neuro Oncol. 2023 Oct 3;25(10):1883-1894. doi: 10.1093/neuonc/noad086. Neuro Oncol. 2023. PMID: 37115514 Free PMC article. Clinical Trial.
Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma.
Akshintala S, Sundby RT, Bernstein D, Glod JW, Kaplan RN, Yohe ME, Gross AM, Derdak J, Lei H, Pan A, Dombi E, Palacio-Yance I, Herrera KR, Miettinen MM, Chen HX, Steinberg SM, Helman LJ, Mascarenhas L, Widemann BC, Navid F, Shern JF, Heske CM. Akshintala S, et al. Among authors: derdak j. Clin Cancer Res. 2023 Sep 1;29(17):3329-3339. doi: 10.1158/1078-0432.CCR-23-0709. Clin Cancer Res. 2023. PMID: 37398992 Free PMC article. Clinical Trial.
15 results