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Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial.
Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, Wegrzynowicz M, Dalley JW, Langer S, Ryazanov S, Leonov A, Griesinger C, Schmidt F, Weckbecker D, Prager K, Matthias T, Giese A. Levin J, et al. Among authors: weckbecker d. EBioMedicine. 2022 Jun;80:104021. doi: 10.1016/j.ebiom.2022.104021. Epub 2022 Apr 29. EBioMedicine. 2022. PMID: 35500536 Free PMC article. Clinical Trial.
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M. Wagner J, et al. Among authors: weckbecker d. Acta Neuropathol. 2015 Nov;130(5):619-31. doi: 10.1007/s00401-015-1483-3. Epub 2015 Oct 6. Acta Neuropathol. 2015. PMID: 26439832 Free PMC article.
Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates.
Reiner AM, Schmidt F, Ryazanov S, Leonov A, Weckbecker D, Deeg AA, Griesinger C, Giese A, Zinth W. Reiner AM, et al. Among authors: weckbecker d. Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):800-807. doi: 10.1016/j.bbagen.2017.12.007. Epub 2017 Dec 19. Biochim Biophys Acta Gen Subj. 2018. PMID: 29273222
11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier.
Maurer A, Leonov A, Ryazanov S, Herfert K, Kuebler L, Buss S, Schmidt F, Weckbecker D, Linder R, Bender D, Giese A, Pichler BJ, Griesinger C. Maurer A, et al. Among authors: weckbecker d. ChemMedChem. 2020 Mar 5;15(5):411-415. doi: 10.1002/cmdc.201900689. Epub 2020 Jan 9. ChemMedChem. 2020. PMID: 31859430 Free PMC article.
[11C]MODAG-001-towards a PET tracer targeting α-synuclein aggregates.
Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, Weckbecker D, Landau AM, Lillethorup TP, Bleher D, Saw RS, Pichler BJ, Griesinger C, Giese A, Herfert K. Kuebler L, et al. Among authors: weckbecker d. Eur J Nucl Med Mol Imaging. 2021 Jun;48(6):1759-1772. doi: 10.1007/s00259-020-05133-x. Epub 2020 Dec 28. Eur J Nucl Med Mol Imaging. 2021. PMID: 33369690 Free PMC article.
Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin.
Camilleri A, Ghio S, Caruana M, Weckbecker D, Schmidt F, Kamp F, Leonov A, Ryazanov S, Griesinger C, Giese A, Cauchi RJ, Vassallo N. Camilleri A, et al. Among authors: weckbecker d. Biochim Biophys Acta Biomembr. 2020 Feb 1;1862(2):183064. doi: 10.1016/j.bbamem.2019.183064. Epub 2019 Sep 12. Biochim Biophys Acta Biomembr. 2020. PMID: 31521630 Free article.
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