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A neutralizing antibody target in early HIV-1 infection was recapitulated in rhesus macaques immunized with the transmitted/founder envelope sequence.
Welbourn S, Chakraborty S, Yang JE, Gleinich AS, Gangadhara S, Khan S, Ferrebee C, Yagnik B, Burton S, Charles T, Smith SA, Williams D, Mopuri R, Upadhyay AA, Thompson J, Price MA, Wang S, Qin Z, Shen X, Williams LD, Eisel N, Peters T, Zhang L, Kilembe W, Karita E, Tomaras GD, Bosinger SE, Amara RR, Azadi P, Wright ER, Gnanakaran S, Derdeyn CA. Welbourn S, et al. Among authors: tomaras gd. PLoS Pathog. 2022 May 3;18(5):e1010488. doi: 10.1371/journal.ppat.1010488. eCollection 2022 May. PLoS Pathog. 2022. PMID: 35503780 Free PMC article.
In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth.
Shen X, Parks RJ, Montefiori DC, Kirchherr JL, Keele BF, Decker JM, Blattner WA, Gao F, Weinhold KJ, Hicks CB, Greenberg ML, Hahn BH, Shaw GM, Haynes BF, Tomaras GD. Shen X, et al. Among authors: tomaras gd. J Virol. 2009 Apr;83(8):3617-25. doi: 10.1128/JVI.02631-08. Epub 2009 Feb 4. J Virol. 2009. PMID: 19193787 Free PMC article.
Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution.
Shen X, Dennison SM, Liu P, Gao F, Jaeger F, Montefiori DC, Verkoczy L, Haynes BF, Alam SM, Tomaras GD. Shen X, et al. Among authors: tomaras gd. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5972-7. doi: 10.1073/pnas.0912381107. Epub 2010 Mar 15. Proc Natl Acad Sci U S A. 2010. PMID: 20231447 Free PMC article.
Strategies for eliciting HIV-1 inhibitory antibodies.
Tomaras GD, Haynes BF. Tomaras GD, et al. Curr Opin HIV AIDS. 2010 Sep;5(5):421-7. doi: 10.1097/COH.0b013e32833d2d45. Curr Opin HIV AIDS. 2010. PMID: 20978384 Free PMC article. Review.
Alterations of the B-cell response by HIV-1 replication.
Shen X, Tomaras GD. Shen X, et al. Among authors: tomaras gd. Curr HIV/AIDS Rep. 2011 Mar;8(1):23-30. doi: 10.1007/s11904-010-0064-2. Curr HIV/AIDS Rep. 2011. PMID: 21161615 Free PMC article.
A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers.
Spearman P, Lally MA, Elizaga M, Montefiori D, Tomaras GD, McElrath MJ, Hural J, De Rosa SC, Sato A, Huang Y, Frey SE, Sato P, Donnelly J, Barnett S, Corey LJ; HIV Vaccine Trials Network of NIAID. Spearman P, et al. Among authors: tomaras gd. J Infect Dis. 2011 Apr 15;203(8):1165-73. doi: 10.1093/infdis/jiq175. J Infect Dis. 2011. PMID: 21451004 Free PMC article. Clinical Trial.
Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual.
Gray ES, Moody MA, Wibmer CK, Chen X, Marshall D, Amos J, Moore PL, Foulger A, Yu JS, Lambson B, Abdool Karim S, Whitesides J, Tomaras GD, Haynes BF, Morris L, Liao HX. Gray ES, et al. Among authors: tomaras gd. J Virol. 2011 Aug;85(15):7719-29. doi: 10.1128/JVI.00563-11. Epub 2011 May 25. J Virol. 2011. PMID: 21613396 Free PMC article.
387 results