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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation.
Konstantinidis E, Molisak A, Perrin F, Streubel-Gallasch L, Fayad S, Kim DY, Petri K, Aryee MJ, Aguilar X, György B, Giedraitis V, Joung JK, Pattanayak V, Essand M, Erlandsson A, Berezovska O, Ingelsson M. Konstantinidis E, et al. Among authors: aguilar x. Mol Ther Nucleic Acids. 2022 Mar 28;28:450-461. doi: 10.1016/j.omtn.2022.03.022. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35505961 Free PMC article.
Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion.
Pagnon de la Vega M, Syvänen S, Giedraitis V, Hooley M, Konstantinidis E, Meier SR, Rokka J, Eriksson J, Aguilar X, Spires-Jones TL, Lannfelt L, Nilsson LNG, Erlandsson A, Hultqvist G, Ingelsson M, Sehlin D. Pagnon de la Vega M, et al. Among authors: aguilar x. Acta Neuropathol Commun. 2024 Feb 5;12(1):22. doi: 10.1186/s40478-024-01734-x. Acta Neuropathol Commun. 2024. PMID: 38317196 Free PMC article.
PET Imaging in Preclinical Anti-Aβ Drug Development.
Syvänen S, Meier SR, Roshanbin S, Xiong M, Faresjö R, Gustavsson T, Bonvicini G, Schlein E, Aguilar X, Julku U, Eriksson J, Sehlin D. Syvänen S, et al. Among authors: aguilar x. Pharm Res. 2022 Jul;39(7):1481-1496. doi: 10.1007/s11095-022-03277-z. Epub 2022 May 2. Pharm Res. 2022. PMID: 35501533 Free PMC article. Review.
48 results