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CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN 1 M146L mutation.
Konstantinidis E, Molisak A, Perrin F, Streubel-Gallasch L, Fayad S, Kim DY, Petri K, Aryee MJ, Aguilar X, György B, Giedraitis V, Joung JK, Pattanayak V, Essand M, Erlandsson A, Berezovska O, Ingelsson M. Konstantinidis E, et al. Among authors: giedraitis v. Mol Ther Nucleic Acids. 2022 Mar 28;28:450-461. doi: 10.1016/j.omtn.2022.03.022. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35505961 Free PMC article.
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.
Blom ES, Giedraitis V, Zetterberg H, Fukumoto H, Blennow K, Hyman BT, Irizarry MC, Wahlund LO, Lannfelt L, Ingelsson M. Blom ES, et al. Among authors: giedraitis v. Dement Geriatr Cogn Disord. 2009;27(5):458-64. doi: 10.1159/000216841. Epub 2009 May 7. Dement Geriatr Cogn Disord. 2009. PMID: 19420940 Free PMC article.
No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration.
Skoglund L, Ingvast S, Matsui T, Freeman SH, Frosch MP, Brundin R, Giedraitis V, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A. Skoglund L, et al. Among authors: giedraitis v. Dement Geriatr Cogn Disord. 2009;28(5):471-5. doi: 10.1159/000260046. Epub 2009 Nov 23. Dement Geriatr Cogn Disord. 2009. PMID: 19940479 Free PMC article.
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Giedraitis V, Glaser A, Sarajärvi T, Brundin R, Gunnarsson MD, Schjeide BM, Tanzi RE, Helisalmi S, Pirttilä T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M. Giedraitis V, et al. Neurosci Lett. 2010 Jan 22;469(2):265-7. doi: 10.1016/j.neulet.2009.12.011. Epub 2009 Dec 23. Neurosci Lett. 2010. PMID: 20005921 Free PMC article.
Cystatin C levels are positively correlated with both Abeta42 and tau levels in cerebrospinal fluid in persons with Alzheimer's disease, mild cognitive impairment, and healthy controls.
Sundelöf J, Sundström J, Hansson O, Eriksdotter-Jönhagen M, Giedraitis V, Larsson A, Degerman-Gunnarsson M, Ingelsson M, Minthon L, Blennow K, Kilander L, Basun H, Lannfelt L. Sundelöf J, et al. Among authors: giedraitis v. J Alzheimers Dis. 2010;21(2):471-8. doi: 10.3233/JAD-2010-091594. J Alzheimers Dis. 2010. PMID: 20555147
Higher cathepsin B levels in plasma in Alzheimer's disease compared to healthy controls.
Sundelöf J, Sundström J, Hansson O, Eriksdotter-Jönhagen M, Giedraitis V, Larsson A, Degerman-Gunnarsson M, Ingelsson M, Minthon L, Blennow K, Kilander L, Basun H, Lannfelt L. Sundelöf J, et al. Among authors: giedraitis v. J Alzheimers Dis. 2010;22(4):1223-30. doi: 10.3233/JAD-2010-101023. J Alzheimers Dis. 2010. PMID: 20930303
142 results