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TLR7 and RIG-I dual-adjuvant loaded nanoparticles drive broadened and synergistic responses in dendritic cells in vitro and generate unique cellular immune responses in influenza vaccination.
Toy R, Keenum MC, Pradhan P, Phang K, Chen P, Chukwu C, Nguyen LAH, Liu J, Jain S, Kozlowski G, Hosten J, Suthar MS, Roy K. Toy R, et al. Among authors: keenum mc. J Control Release. 2021 Feb 10;330:866-877. doi: 10.1016/j.jconrel.2020.10.060. Epub 2020 Nov 5. J Control Release. 2021. PMID: 33160004 Free PMC article.
Nanoparticle-delivered TLR4 and RIG-I agonists enhance immune response to SARS-CoV-2 subunit vaccine.
Atalis A, Keenum MC, Pandey B, Beach A, Pradhan P, Vantucci C, Jain R, Hosten J, Smith C, Kramer L, Jimenez A, Ochoa MA, Frey D, Roy K. Atalis A, et al. Among authors: keenum mc. bioRxiv [Preprint]. 2022 Feb 2:2022.01.31.478507. doi: 10.1101/2022.01.31.478507. bioRxiv. 2022. Update in: J Control Release. 2022 Jul;347:476-488. doi: 10.1016/j.jconrel.2022.05.023 PMID: 35132413 Free PMC article. Updated. Preprint.