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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.
Oberkersch RE, Pontarin G, Astone M, Spizzotin M, Arslanbaeva L, Tosi G, Panieri E, Ricciardi S, Allega MF, Brossa A, Grumati P, Bussolati B, Biffo S, Tardito S, Santoro MM. Oberkersch RE, et al. Among authors: tardito s. Dev Cell. 2022 May 23;57(10):1241-1256.e8. doi: 10.1016/j.devcel.2022.04.018. Epub 2022 May 16. Dev Cell. 2022. PMID: 35580611 Free article.
A map of the altered glioma metabolism.
Deshmukh R, Allega MF, Tardito S. Deshmukh R, et al. Among authors: tardito s. Trends Mol Med. 2021 Nov;27(11):1045-1059. doi: 10.1016/j.molmed.2021.07.011. Epub 2021 Sep 3. Trends Mol Med. 2021. PMID: 34489164 Review.
Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer.
Villar VH, Allega MF, Deshmukh R, Ackermann T, Nakasone MA, Vande Voorde J, Drake TM, Oetjen J, Bloom A, Nixon C, Müller M, May S, Tan EH, Vereecke L, Jans M, Blancke G, Murphy DJ, Huang DT, Lewis DY, Bird TG, Sansom OJ, Blyth K, Sumpton D, Tardito S. Villar VH, et al. Among authors: tardito s. Nat Chem Biol. 2023 Mar;19(3):292-300. doi: 10.1038/s41589-022-01154-9. Epub 2022 Oct 24. Nat Chem Biol. 2023. PMID: 36280791 Free PMC article.
Cancer metabolism at a glance.
Vazquez A, Kamphorst JJ, Markert EK, Schug ZT, Tardito S, Gottlieb E. Vazquez A, et al. Among authors: tardito s. J Cell Sci. 2016 Sep 15;129(18):3367-73. doi: 10.1242/jcs.181016. J Cell Sci. 2016. PMID: 27635066 Free PMC article. Review.
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress.
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E. Schug ZT, et al. Among authors: tardito s. Cancer Cell. 2015 Jan 12;27(1):57-71. doi: 10.1016/j.ccell.2014.12.002. Cancer Cell. 2015. PMID: 25584894 Free PMC article.
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A, Murta T, Race AM, Sumpton D, Vlahov N, Gay DM, Knight JRP, Jackstadt R, Leach JDG, Ridgway RA, Johnson ER, Nixon C, Hedley A, Gilroy K, Clark W, Malla SB, Dunne PD, Rodriguez-Blanco G, Critchlow SE, Mrowinska A, Malviya G, Solovyev D, Brown G, Lewis DY, Mackay GM, Strathdee D, Tardito S, Gottlieb E; CRUK Rosetta Grand Challenge Consortium; Takats Z, Barry ST, Goodwin RJA, Bunch J, Bushell M, Campbell AD, Sansom OJ. Najumudeen AK, et al. Among authors: tardito s. Nat Genet. 2021 Jan;53(1):16-26. doi: 10.1038/s41588-020-00753-3. Epub 2021 Jan 7. Nat Genet. 2021. PMID: 33414552
An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism.
Gonzalez-Menendez P, Romano M, Yan H, Deshmukh R, Papoin J, Oburoglu L, Daumur M, Dumé AS, Phadke I, Mongellaz C, Qu X, Bories PN, Fontenay M, An X, Dardalhon V, Sitbon M, Zimmermann VS, Gallagher PG, Tardito S, Blanc L, Mohandas N, Taylor N, Kinet S. Gonzalez-Menendez P, et al. Among authors: tardito s. Cell Rep. 2021 Feb 2;34(5):108723. doi: 10.1016/j.celrep.2021.108723. Cell Rep. 2021. PMID: 33535038 Free PMC article.
Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.
Matias MI, Yong CS, Foroushani A, Goldsmith C, Mongellaz C, Sezgin E, Levental KR, Talebi A, Perrault J, Rivière A, Dehairs J, Delos O, Bertand-Michel J, Portais JC, Wong M, Marie JC, Kelekar A, Kinet S, Zimmermann VS, Levental I, Yvan-Charvet L, Swinnen JV, Muljo SA, Hernandez-Vargas H, Tardito S, Taylor N, Dardalhon V. Matias MI, et al. Among authors: tardito s. Cell Rep. 2021 Nov 2;37(5):109911. doi: 10.1016/j.celrep.2021.109911. Cell Rep. 2021. PMID: 34731632 Free PMC article.
76 results