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The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracil.
Kiweler N, Schwarz H, Nguyen A, Matschos S, Mullins C, Piée-Staffa A, Brachetti C, Roos WP, Schneider G, Linnebacher M, Brenner W, Krämer OH. Kiweler N, et al. Among authors: piee staffa a. Cell Biol Toxicol. 2023 Oct;39(5):2401-2419. doi: 10.1007/s10565-022-09731-3. Epub 2022 May 24. Cell Biol Toxicol. 2023. PMID: 35608750 Free PMC article.
Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells.
Marx C, Sonnemann J, Beyer M, Maddocks ODK, Lilla S, Hauzenberger I, Piée-Staffa A, Siniuk K, Nunna S, Marx-Blümel L, Westermann M, Wagner T, Meyer FB, Thierbach R, Mullins CS, Kdimati S, Linnebacher M, Neri F, Heinzel T, Wang ZQ, Krämer OH. Marx C, et al. Among authors: piee staffa a. Mol Oncol. 2021 Dec;15(12):3404-3429. doi: 10.1002/1878-0261.13060. Epub 2021 Jul 29. Mol Oncol. 2021. PMID: 34258881 Free PMC article.
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3.
Wachholz V, Mustafa AM, Zeyn Y, Henninger SJ, Beyer M, Dzulko M, Piée-Staffa A, Brachetti C, Haehnel PS, Sellmer A, Mahboobi S, Kindler T, Brenner W, Nikolova T, Krämer OH. Wachholz V, et al. Among authors: piee staffa a. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19. Arch Toxicol. 2022. PMID: 34665271 Free PMC article.
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells.
Fischer MA, Mustafa AM, Hausmann K, Ashry R, Kansy AG, Liebl MC, Brachetti C, Piée-Staffa A, Zessin M, Ibrahim HS, Hofmann TG, Schutkowski M, Sippl W, Krämer OH. Fischer MA, et al. Among authors: piee staffa a. J Adv Res. 2024 Jun;60:201-214. doi: 10.1016/j.jare.2023.07.005. Epub 2023 Jul 17. J Adv Res. 2024. PMID: 37467961 Free PMC article.
Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death.
Kaina B, Mühlhausen U, Piee-Staffa A, Christmann M, Garcia Boy R, Rösch F, Schirrmacher R. Kaina B, et al. Among authors: piee staffa a. J Pharmacol Exp Ther. 2004 Nov;311(2):585-93. doi: 10.1124/jpet.104.071316. Epub 2004 Jul 13. J Pharmacol Exp Ther. 2004. PMID: 15254145
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