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IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function.
Kotas ME, Moore CM, Gurrola JG 2nd, Pletcher SD, Goldberg AN, Alvarez R, Yamato S, Bratcher PE, Shaughnessy CA, Zeitlin PL, Zhang IH, Li Y, Montgomery MT, Lee K, Cope EK, Locksley RM, Seibold MA, Gordon ED. Kotas ME, et al. Among authors: seibold ma. JCI Insight. 2022 Jul 8;7(13):e159832. doi: 10.1172/jci.insight.159832. JCI Insight. 2022. PMID: 35608904 Free PMC article.
Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein.
Seibold MA, Reese TA, Choudhry S, Salam MT, Beckman K, Eng C, Atakilit A, Meade K, Lenoir M, Watson HG, Thyne S, Kumar R, Weiss KB, Grammer LC, Avila P, Schleimer RP, Fahy JV, Rodriguez-Santana J, Rodriguez-Cintron W, Boot RG, Sheppard D, Gilliland FD, Locksley RM, Burchard EG. Seibold MA, et al. J Biol Chem. 2009 Jul 17;284(29):19650-8. doi: 10.1074/jbc.M109.012443. Epub 2009 May 12. J Biol Chem. 2009. PMID: 19435888 Free PMC article.
Alternative splicing of interleukin-33 and type 2 inflammation in asthma.
Gordon ED, Simpson LJ, Rios CL, Ringel L, Lachowicz-Scroggins ME, Peters MC, Wesolowska-Andersen A, Gonzalez JR, MacLeod HJ, Christian LS, Yuan S, Barry L, Woodruff PG, Ansel KM, Nocka K, Seibold MA, Fahy JV. Gordon ED, et al. Among authors: seibold ma. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8765-70. doi: 10.1073/pnas.1601914113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432971 Free PMC article.
IL1RL1 asthma risk variants regulate airway type 2 inflammation.
Gordon ED, Palandra J, Wesolowska-Andersen A, Ringel L, Rios CL, Lachowicz-Scroggins ME, Sharp LZ, Everman JL, MacLeod HJ, Lee JW, Mason RJ, Matthay MA, Sheldon RT, Peters MC, Nocka KH, Fahy JV, Seibold MA. Gordon ED, et al. Among authors: seibold ma. JCI Insight. 2016 Sep 8;1(14):e87871. doi: 10.1172/jci.insight.87871. JCI Insight. 2016. PMID: 27699235 Free PMC article.
Lipid abnormalities in atopic skin are driven by type 2 cytokines.
Berdyshev E, Goleva E, Bronova I, Dyjack N, Rios C, Jung J, Taylor P, Jeong M, Hall CF, Richers BN, Norquest KA, Zheng T, Seibold MA, Leung DY. Berdyshev E, et al. Among authors: seibold ma. JCI Insight. 2018 Feb 22;3(4):e98006. doi: 10.1172/jci.insight.98006. eCollection 2018 Feb 22. JCI Insight. 2018. PMID: 29467325 Free PMC article. Clinical Trial.
The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.
Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW. Schaefer N, et al. Among authors: seibold ma. JCI Insight. 2019 Apr 18;4(8):e127237. doi: 10.1172/jci.insight.127237. eCollection 2019 Apr 18. JCI Insight. 2019. PMID: 30996135 Free PMC article.
Genome-Wide Analysis Reveals Mucociliary Remodeling of the Nasal Airway Epithelium Induced by Urban PM2.5.
Montgomery MT, Sajuthi SP, Cho SH, Everman JL, Rios CL, Goldfarbmuren KC, Jackson ND, Saef B, Cromie M, Eng C, Medina V, Elhawary JR, Oh SS, Rodriguez-Santana J, Vladar EK, Burchard EG, Seibold MA. Montgomery MT, et al. Among authors: seibold ma. Am J Respir Cell Mol Biol. 2020 Aug;63(2):172-184. doi: 10.1165/rcmb.2019-0454OC. Am J Respir Cell Mol Biol. 2020. PMID: 32275839 Free PMC article.
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
Peters MC, Sajuthi S, Deford P, Christenson S, Rios CL, Montgomery MT, Woodruff PG, Mauger DT, Erzurum SC, Johansson MW, Denlinger LC, Jarjour NN, Castro M, Hastie AT, Moore W, Ortega VE, Bleecker ER, Wenzel SE, Israel E, Levy BD, Seibold MA, Fahy JV. Peters MC, et al. Among authors: seibold ma. Am J Respir Crit Care Med. 2020 Jul 1;202(1):83-90. doi: 10.1164/rccm.202003-0821OC. Am J Respir Crit Care Med. 2020. PMID: 32348692 Free PMC article.
116 results