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Empagliflozin effects on iron metabolism as a possible mechanism for improved clinical outcomes in non-diabetic patients with systolic heart failure.
Angermann CE, Santos-Gallego CG, Requena-Ibanez JA, Sehner S, Zeller T, Gerhardt LMS, Maack C, Sanz J, Frantz S, Fuster V, Ertl G, Badimon JJ. Angermann CE, et al. Among authors: gerhardt lms. Nat Cardiovasc Res. 2023 Nov;2(11):1032-1043. doi: 10.1038/s44161-023-00352-5. Epub 2023 Oct 26. Nat Cardiovasc Res. 2023. PMID: 39196095 Free PMC article. Clinical Trial.
Multi-omic approaches to acute kidney injury and repair.
Gerhardt LMS, McMahon AP. Gerhardt LMS, et al. Curr Opin Biomed Eng. 2021 Dec;20:100344. doi: 10.1016/j.cobme.2021.100344. Epub 2021 Sep 21. Curr Opin Biomed Eng. 2021. PMID: 35005326 Free PMC article.
Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression.
Lindau A, Härdtner C, Hergeth SP, Blanz KD, Dufner B, Hoppe N, Anto-Michel N, Kornemann J, Zou J, Gerhardt LM, Heidt T, Willecke F, Geis S, Stachon P, Wolf D, Libby P, Swirski FK, Robbins CS, McPheat W, Hawley S, Braddock M, Gilsbach R, Hein L, von zur Mühlen C, Bode C, Zirlik A, Hilgendorf I. Lindau A, et al. Basic Res Cardiol. 2016 Mar;111(2):20. doi: 10.1007/s00395-016-0535-8. Epub 2016 Feb 18. Basic Res Cardiol. 2016. PMID: 26891724 Free PMC article.
Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Robbins CS, et al. Nat Med. 2013 Sep;19(9):1166-72. doi: 10.1038/nm.3258. Epub 2013 Aug 11. Nat Med. 2013. PMID: 23933982 Free PMC article.
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.
Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Hilgendorf I, et al. Circulation. 2014 Apr 22;129(16):1677-87. doi: 10.1161/CIRCULATIONAHA.113.006381. Epub 2014 Jan 31. Circulation. 2014. PMID: 24488984 Free PMC article.
Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium.
Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Hilgendorf I, et al. Circ Res. 2014 May 9;114(10):1611-22. doi: 10.1161/CIRCRESAHA.114.303204. Epub 2014 Mar 13. Circ Res. 2014. PMID: 24625784 Free PMC article.
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