Luciani R - Search Results

1

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.

Pöhner I, Quotadamo A, Panecka-Hofman J, Luciani R, Santucci M, Linciano P, Landi G, Di Pisa F, Dello Iacono L, Pozzi C, Mangani S, Gul S, Witt G, Ellinger B, Kuzikov M, Santarem N, Cordeiro-da-Silva A, Costi MP, Venturelli A, Wade RC. Pöhner I, et al. Among authors: luciani r. J Med Chem. 2022 Jul 14;65(13):9011-9033. doi: 10.1021/acs.jmedchem.2c00232. Epub 2022 Jun 8. J Med Chem. 2022. PMID: 35675511 Free PMC article.

2

Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells.

Marverti G, Ligabue A, Paglietti G, Corona P, Piras S, Vitale G, Guerrieri D, Luciani R, Costi MP, Frassineti C, Moruzzi MS. Marverti G, et al. Among authors: luciani r. Eur J Pharmacol. 2009 Aug 1;615(1-3):17-26. doi: 10.1016/j.ejphar.2009.04.062. Epub 2009 May 14. Eur J Pharmacol. 2009. PMID: 19446547

3

Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors.

Carosati E, Sforna G, Pippi M, Marverti G, Ligabue A, Guerrieri D, Piras S, Guaitoli G, Luciani R, Costi MP, Cruciani G. Carosati E, et al. Among authors: luciani r. Bioorg Med Chem. 2010 Nov 15;18(22):7773-85. doi: 10.1016/j.bmc.2010.09.065. Epub 2010 Oct 1. Bioorg Med Chem. 2010. PMID: 20951595

4

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

Ferrari S, Morandi F, Motiejunas D, Nerini E, Henrich S, Luciani R, Venturelli A, Lazzari S, Calò S, Gupta S, Hannaert V, Michels PA, Wade RC, Costi MP. Ferrari S, et al. Among authors: luciani r. J Med Chem. 2011 Jan 13;54(1):211-21. doi: 10.1021/jm1010572. Epub 2010 Dec 2. J Med Chem. 2011. PMID: 21126022

5

Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.

Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP. Mangani S, et al. Among authors: luciani r. J Med Chem. 2011 Aug 11;54(15):5454-67. doi: 10.1021/jm2005018. Epub 2011 Jul 12. J Med Chem. 2011. PMID: 21696158

6

Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.

Cardinale D, Guaitoli G, Tondi D, Luciani R, Henrich S, Salo-Ahen OM, Ferrari S, Marverti G, Guerrieri D, Ligabue A, Frassineti C, Pozzi C, Mangani S, Fessas D, Guerrini R, Ponterini G, Wade RC, Costi MP. Cardinale D, et al. Among authors: luciani r. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E542-9. doi: 10.1073/pnas.1104829108. Epub 2011 Jul 27. Proc Natl Acad Sci U S A. 2011. PMID: 21795601 Free PMC article.

7

Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.

Corona P, Gibellini F, Cavalli A, Saxena P, Carta A, Loriga M, Luciani R, Paglietti G, Guerrieri D, Nerini E, Gupta S, Hannaert V, Michels PA, Ferrari S, Costi PM. Corona P, et al. Among authors: luciani r. J Med Chem. 2012 Oct 11;55(19):8318-29. doi: 10.1021/jm300563f. Epub 2012 Sep 19. J Med Chem. 2012. PMID: 22946585

8

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism.

Pozzi C, Ferrari S, Cortesi D, Luciani R, Stroud RM, Catalano A, Costi MP, Mangani S. Pozzi C, et al. Among authors: luciani r. Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1232-41. doi: 10.1107/S0907444912026236. Epub 2012 Aug 18. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22948925 Free PMC article.

9

Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.

Carosati E, Tochowicz A, Marverti G, Guaitoli G, Benedetti P, Ferrari S, Stroud RM, Finer-Moore J, Luciani R, Farina D, Cruciani G, Costi MP. Carosati E, et al. Among authors: luciani r. J Med Chem. 2012 Nov 26;55(22):10272-6. doi: 10.1021/jm300850v. Epub 2012 Nov 5. J Med Chem. 2012. PMID: 23075414

10

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.

Ferrari S, Calò S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. Ferrari S, et al. Among authors: luciani r. J Med Chem. 2013 Nov 27;56(22):9356-60. doi: 10.1021/jm4014086. Epub 2013 Nov 13. J Med Chem. 2013. PMID: 24147825

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