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Page 1
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.
Pöhner I, Quotadamo A, Panecka-Hofman J, Luciani R, Santucci M, Linciano P, Landi G, Di Pisa F, Dello Iacono L, Pozzi C, Mangani S, Gul S, Witt G, Ellinger B, Kuzikov M, Santarem N, Cordeiro-da-Silva A, Costi MP, Venturelli A, Wade RC. Pöhner I, et al. Among authors: mangani s. J Med Chem. 2022 Jul 14;65(13):9011-9033. doi: 10.1021/acs.jmedchem.2c00232. Epub 2022 Jun 8. J Med Chem. 2022. PMID: 35675511 Free PMC article.
Homodimeric enzymes as drug targets.
Cardinale D, Salo-Ahen OM, Ferrari S, Ponterini G, Cruciani G, Carosati E, Tochowicz AM, Mangani S, Wade RC, Costi MP. Cardinale D, et al. Among authors: mangani s. Curr Med Chem. 2010;17(9):826-46. doi: 10.2174/092986710790712156. Curr Med Chem. 2010. PMID: 20156173 Review.
Protein-protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase.
Cardinale D, Guaitoli G, Tondi D, Luciani R, Henrich S, Salo-Ahen OM, Ferrari S, Marverti G, Guerrieri D, Ligabue A, Frassineti C, Pozzi C, Mangani S, Fessas D, Guerrini R, Ponterini G, Wade RC, Costi MP. Cardinale D, et al. Among authors: mangani s. Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E542-9. doi: 10.1073/pnas.1104829108. Epub 2011 Jul 27. Proc Natl Acad Sci U S A. 2011. PMID: 21795601 Free PMC article.
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Salo-Ahen OM, et al. Among authors: mangani s. J Med Chem. 2015 Apr 23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25798950 Free PMC article.
Iron binding to human heavy-chain ferritin.
Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P, Mangani S. Pozzi C, et al. Among authors: mangani s. Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1909-20. doi: 10.1107/S1399004715013073. Epub 2015 Aug 25. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 26327381
137 results