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Page 1
Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators.
Tsujikawa LM, Kharenko OA, Stotz SC, Rakai BD, Sarsons CD, Gilham D, Wasiak S, Fu L, Sweeney M, Johansson JO, Wong NCW, Kulikowski E. Tsujikawa LM, et al. Among authors: kharenko oa. Biomed Pharmacother. 2022 Aug;152:113230. doi: 10.1016/j.biopha.2022.113230. Epub 2022 Jun 7. Biomed Pharmacother. 2022. PMID: 35687908 Free article.
RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.
McLure KG, Gesner EM, Tsujikawa L, Kharenko OA, Attwell S, Campeau E, Wasiak S, Stein A, White A, Fontano E, Suto RK, Wong NC, Wagner GS, Hansen HC, Young PR. McLure KG, et al. Among authors: kharenko oa. PLoS One. 2013 Dec 31;8(12):e83190. doi: 10.1371/journal.pone.0083190. eCollection 2013. PLoS One. 2013. PMID: 24391744 Free PMC article.
Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design.
Duffy BC, Liu S, Martin GS, Wang R, Hsia MM, Zhao H, Guo C, Ellis M, Quinn JF, Kharenko OA, Norek K, Gesner EM, Young PR, McLure KG, Wagner GS, Lakshminarasimhan D, White A, Suto RK, Hansen HC, Kitchen DB. Duffy BC, et al. Among authors: kharenko oa. Bioorg Med Chem Lett. 2015 Jul 15;25(14):2818-23. doi: 10.1016/j.bmcl.2015.04.107. Epub 2015 May 11. Bioorg Med Chem Lett. 2015. PMID: 26022843
Novel approaches to targeting BRD4.
Kharenko OA, Hansen HC. Kharenko OA, et al. Drug Discov Today Technol. 2017 Jun;24:19-24. doi: 10.1016/j.ddtec.2017.10.003. Epub 2017 Oct 28. Drug Discov Today Technol. 2017. PMID: 29233295 Review.
RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
Kharenko OA, Gesner EM, Patel RG, Norek K, White A, Fontano E, Suto RK, Young PR, McLure KG, Hansen HC. Kharenko OA, et al. Biochem Biophys Res Commun. 2016 Aug 12;477(1):62-67. doi: 10.1016/j.bbrc.2016.06.021. Epub 2016 Jun 6. Biochem Biophys Res Commun. 2016. PMID: 27282480
Synthesis of NVS-BPTF-1 and evaluation of its biological activity.
Mélin L, Calosing C, Kharenko OA, Hansen HC, Gagnon A. Mélin L, et al. Among authors: kharenko oa. Bioorg Med Chem Lett. 2021 Sep 1;47:128208. doi: 10.1016/j.bmcl.2021.128208. Epub 2021 Jun 16. Bioorg Med Chem Lett. 2021. PMID: 34146702
Molecular mechanisms in the activation of abscisic acid receptor PYR1.
Dorosh L, Kharenko OA, Rajagopalan N, Loewen MC, Stepanova M. Dorosh L, et al. Among authors: kharenko oa. PLoS Comput Biol. 2013;9(6):e1003114. doi: 10.1371/journal.pcbi.1003114. Epub 2013 Jun 27. PLoS Comput Biol. 2013. PMID: 23825939 Free PMC article.
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