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Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
Frankowski KJ, Patnaik S, Wang C, Southall N, Dutta D, De S, Li D, Dextras C, Lin YH, Bryant-Connah M, Davis D, Wang F, Wachsmuth LM, Shah P, Williams J, Kabir M, Zhu E, Baljinnyam B, Wang A, Xu X, Norton J, Ferrer M, Titus S, Simeonov A, Zheng W, Mathews Griner LA, Jadhav A, Aubé J, Henderson MJ, Rudloff U, Schoenen FJ, Huang S, Marugan JJ. Frankowski KJ, et al. Among authors: patnaik s. J Med Chem. 2022 Jun 23;65(12):8303-8331. doi: 10.1021/acs.jmedchem.2c00204. Epub 2022 Jun 13. J Med Chem. 2022. PMID: 35696646 Free PMC article.
Multi-gram scale synthesis of FR180204.
Patnaik S, Dietz HC, Zheng W, Austin C, Marugan JJ. Patnaik S, et al. J Org Chem. 2009 Nov 20;74(22):8870-3. doi: 10.1021/jo901835m. J Org Chem. 2009. PMID: 19852504 Free PMC article.
Non-iminosugar glucocerebrosidase small molecule chaperones.
Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E. Marugan JJ, et al. Among authors: patnaik s. Medchemcomm. 2012 Jan;3(1):56-60. doi: 10.1039/C1MD00200G. Epub 2011 Oct 24. Medchemcomm. 2012. PMID: 22606365 Free PMC article.
A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats.
Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, Patnaik S, Marugan J, Damadzic R, Dehdashti SJ, Schwandt ML, Southall N, Austin CP, Eskay R, Ciccocioppo R, Zheng W, Heilig M. Thorsell A, et al. Among authors: patnaik s. J Neurosci. 2013 Jun 12;33(24):10132-42. doi: 10.1523/JNEUROSCI.4742-12.2013. J Neurosci. 2013. PMID: 23761908 Free PMC article.
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Krueger AB, et al. Among authors: patnaik s. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. J Biol Chem. 2014. PMID: 24755226 Free PMC article.
715 results