Pflum MKH - Search Results

1

Evidence that HDAC7 acts as an epigenetic "reader" of AR acetylation through NCoR-HDAC3 dissociation.

Zhang Y, Andrade R, Hanna AA, Pflum MKH. Zhang Y, et al. Among authors: pflum mkh. Cell Chem Biol. 2022 Jul 21;29(7):1162-1173.e5. doi: 10.1016/j.chembiol.2022.05.008. Epub 2022 Jun 15. Cell Chem Biol. 2022. PMID: 35709754 Free PMC article.

2

Isoform-selective histone deacetylase inhibitors.

Bieliauskas AV, Pflum MK. Bieliauskas AV, et al. Chem Soc Rev. 2008 Jul;37(7):1402-13. doi: 10.1039/b703830p. Epub 2008 May 8. Chem Soc Rev. 2008. PMID: 18568166 Free PMC article. Review.

3

Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors.

Weerasinghe SV, Estiu G, Wiest O, Pflum MK. Weerasinghe SV, et al. J Med Chem. 2008 Sep 25;51(18):5542-51. doi: 10.1021/jm800081j. Epub 2008 Aug 27. J Med Chem. 2008. PMID: 18729444 Free PMC article.

4

A histone deacetylase-dependent screen in yeast.

Weerasinghe SV, Wambua M, Pflum MK. Weerasinghe SV, et al. Bioorg Med Chem. 2010 Nov 1;18(21):7586-92. doi: 10.1016/j.bmc.2010.08.045. Epub 2010 Sep 20. Bioorg Med Chem. 2010. PMID: 20863708 Free PMC article.

5

The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.

Choi SE, Pflum MK. Choi SE, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7084-6. doi: 10.1016/j.bmcl.2012.09.093. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23089527 Free PMC article.

6

Development of an ELISA-Based HDAC Activity Assay for Characterization of Isoform-Selective Inhibitors.

Padige G, Negmeldin AT, Pflum MK. Padige G, et al. J Biomol Screen. 2015 Dec;20(10):1277-85. doi: 10.1177/1087057115598118. Epub 2015 Jul 31. J Biomol Screen. 2015. PMID: 26232305

7

Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid.

Bieliauskas AV, Weerasinghe SV, Negmeldin AT, Pflum MK. Bieliauskas AV, et al. Arch Pharm (Weinheim). 2016 May;349(5):373-82. doi: 10.1002/ardp.201500472. Epub 2016 Apr 9. Arch Pharm (Weinheim). 2016. PMID: 27062198 Free PMC article.

8

LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.

Nalawansha DA, Pflum MK. Nalawansha DA, et al. ACS Chem Biol. 2017 Jan 20;12(1):254-264. doi: 10.1021/acschembio.6b00776. Epub 2016 Dec 15. ACS Chem Biol. 2017. PMID: 27977115 Free PMC article.

9

HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation.

Nalawansha DA, Gomes ID, Wambua MK, Pflum MKH. Nalawansha DA, et al. Among authors: pflum mkh. Cell Chem Biol. 2017 Apr 20;24(4):481-492.e5. doi: 10.1016/j.chembiol.2017.03.008. Epub 2017 Apr 6. Cell Chem Biol. 2017. PMID: 28392145 Free PMC article.

10

The structural requirements of histone deacetylase inhibitors: SAHA analogs modified at the C5 position display dual HDAC6/8 selectivity.

Negmeldin AT, Pflum MKH. Negmeldin AT, et al. Among authors: pflum mkh. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3254-3258. doi: 10.1016/j.bmcl.2017.06.033. Epub 2017 Jun 13. Bioorg Med Chem Lett. 2017. PMID: 28648461 Free PMC article.

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