Egli M - Search Results

1

From bench to bedside: Improving the clinical safety of GalNAc-siRNA conjugates using seed-pairing destabilization.

Schlegel MK, Janas MM, Jiang Y, Barry JD, Davis W, Agarwal S, Berman D, Brown CR, Castoreno A, LeBlanc S, Liebow A, Mayo T, Milstein S, Nguyen T, Shulga-Morskaya S, Hyde S, Schofield S, Szeto J, Woods LB, Yilmaz VO, Manoharan M, Egli M, Charissé K, Sepp-Lorenzino L, Haslett P, Fitzgerald K, Jadhav V, Maier MA. Schlegel MK, et al. Among authors: egli m. Nucleic Acids Res. 2022 Jul 8;50(12):6656-6670. doi: 10.1093/nar/gkac539. Nucleic Acids Res. 2022. PMID: 35736224 Free PMC article.

2

Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.

Tereshko V, Wilds CJ, Minasov G, Prakash TP, Maier MA, Howard A, Wawrzak Z, Manoharan M, Egli M. Tereshko V, et al. Among authors: egli m. Nucleic Acids Res. 2001 Mar 1;29(5):1208-15. doi: 10.1093/nar/29.5.1208. Nucleic Acids Res. 2001. PMID: 11222771 Free PMC article.

3

Direct observation of a cytosine analogue that forms five hydrogen bonds to guanosine: guanidino G-clamp.

Wilds CJ, Maier MA, Tereshko V, Manoharan M, Egli M. Wilds CJ, et al. Among authors: egli m. Angew Chem Int Ed Engl. 2002 Jan 4;41(1):115-7. doi: 10.1002/1521-3773(20020104)41:1<115::aid-anie115>3.0.co;2-r. Angew Chem Int Ed Engl. 2002. PMID: 12491456 No abstract available.

4

Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.

Pattanayek R, Sethaphong L, Pan C, Prhavc M, Prakash TP, Manoharan M, Egli M. Pattanayek R, et al. Among authors: egli m. J Am Chem Soc. 2004 Nov 24;126(46):15006-7. doi: 10.1021/ja044637k. J Am Chem Soc. 2004. PMID: 15547979

5

Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines.

Diop-Frimpong B, Prakash TP, Rajeev KG, Manoharan M, Egli M. Diop-Frimpong B, et al. Among authors: egli m. Nucleic Acids Res. 2005 Sep 16;33(16):5297-307. doi: 10.1093/nar/gki823. Print 2005. Nucleic Acids Res. 2005. PMID: 16170156 Free PMC article.

6

2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H.

Li F, Sarkhel S, Wilds CJ, Wawrzak Z, Prakash TP, Manoharan M, Egli M. Li F, et al. Among authors: egli m. Biochemistry. 2006 Apr 4;45(13):4141-52. doi: 10.1021/bi052322r. Biochemistry. 2006. PMID: 16566588 Free PMC article.

7

Gene silencing activity of siRNAs with a ribo-difluorotoluyl nucleotide.

Xia J, Noronha A, Toudjarska I, Li F, Akinc A, Braich R, Frank-Kamenetsky M, Rajeev KG, Egli M, Manoharan M. Xia J, et al. Among authors: egli m. ACS Chem Biol. 2006 Apr 25;1(3):176-83. doi: 10.1021/cb600063p. ACS Chem Biol. 2006. PMID: 17163665

8

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.

Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M. Li F, et al. Among authors: egli m. Nucleic Acids Res. 2007;35(19):6424-38. doi: 10.1093/nar/gkm664. Epub 2007 Sep 18. Nucleic Acids Res. 2007. PMID: 17881374 Free PMC article.

9

Backbone-base inclination as a fundamental determinant of nucleic acid self- and cross-pairing.

Pallan PS, Lubini P, Bolli M, Egli M. Pallan PS, et al. Among authors: egli m. Nucleic Acids Res. 2007;35(19):6611-24. doi: 10.1093/nar/gkm612. Epub 2007 Sep 28. Nucleic Acids Res. 2007. PMID: 17905816 Free PMC article.

The crystal structure of the duplex formed by oligo(2',3'-dideoxy-beta-d-glucopyranosyl)nucleotides (homo-DNA) revealed strongly inclined backbone and base-pair axes [Egli,M., Pallan,P.S., Pattanayek,R., Wilds,C.J., Lubini,P., Minasov,G., Dobler,M., Leumann,C …

The crystal structure of the duplex formed by oligo(2',3'-dideoxy-beta-d-glucopyranosyl)nucleotides (homo-DNA) revealed strongly inclined ba …

10

A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.

Pallan PS, Prakash TP, Li F, Eoff RL, Manoharan M, Egli M. Pallan PS, et al. Among authors: egli m. Chem Commun (Camb). 2009 Apr 21;(15):2017-9. doi: 10.1039/b822781k. Epub 2009 Feb 26. Chem Commun (Camb). 2009. PMID: 19333476 Free PMC article.

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