El-Gamal D - Search Results

1

A Novel Triple-Action Inhibitor Targeting B-Cell Receptor Signaling and BRD4 Demonstrates Preclinical Activity in Chronic Lymphocytic Leukemia.

Smith AL, Eiken AP, Skupa SA, Moore DY, Umeta LT, Smith LM, Lyden ER, D'Angelo CR, Kallam A, Vose JM, Kutateladze TG, El-Gamal D. Smith AL, et al. Int J Mol Sci. 2022 Jun 16;23(12):6712. doi: 10.3390/ijms23126712. Int J Mol Sci. 2022. PMID: 35743155 Free PMC article.

2

PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.

El-Gamal D, Williams K, LaFollette TD, Cannon M, Blachly JS, Zhong Y, Woyach JA, Williams E, Awan FT, Jones J, Andritsos L, Maddocks K, Wu CH, Chen CS, Lehman A, Zhang X, Lapalombella R, Byrd JC. El-Gamal D, et al. Blood. 2014 Aug 28;124(9):1481-91. doi: 10.1182/blood-2014-05-574830. Epub 2014 Jul 7. Blood. 2014. PMID: 25001469 Free PMC article.

3

Targeting BTK through microRNA in chronic lymphocytic leukemia.

Bottoni A, Rizzotto L, Lai TH, Liu C, Smith LL, Mantel R, Reiff S, El-Gamal D, Larkin K, Johnson AJ, Lapalombella R, Lehman A, Plunkett W, Byrd JC, Blachly JS, Woyach JA, Sampath D. Bottoni A, et al. Blood. 2016 Dec 29;128(26):3101-3112. doi: 10.1182/blood-2016-07-727750. Epub 2016 Oct 17. Blood. 2016. PMID: 27756747 Free PMC article.

4

BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor.

Ozer HG, El-Gamal D, Powell B, Hing ZA, Blachly JS, Harrington B, Mitchell S, Grieselhuber NR, Williams K, Lai TH, Alinari L, Baiocchi RA, Brinton L, Baskin E, Cannon M, Beaver L, Goettl VM, Lucas DM, Woyach JA, Sampath D, Lehman AM, Yu L, Zhang J, Ma Y, Zhang Y, Spevak W, Shi S, Severson P, Shellooe R, Carias H, Tsang G, Dong K, Ewing T, Marimuthu A, Tantoy C, Walters J, Sanftner L, Rezaei H, Nespi M, Matusow B, Habets G, Ibrahim P, Zhang C, Mathé EA, Bollag G, Byrd JC, Lapalombella R. Ozer HG, et al. Cancer Discov. 2018 Apr;8(4):458-477. doi: 10.1158/2159-8290.CD-17-0902. Epub 2018 Jan 31. Cancer Discov. 2018. PMID: 29386193 Free PMC article.

5

Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.

Gilham D, Smith AL, Fu L, Moore DY, Muralidharan A, Reid SPM, Stotz SC, Johansson JO, Sweeney M, Wong NCW, Kulikowski E, El-Gamal D. Gilham D, et al. Biomedicines. 2021 Apr 18;9(4):437. doi: 10.3390/biomedicines9040437. Biomedicines. 2021. PMID: 33919584 Free PMC article.

6

The BTK/PI3K/BRD4 axis inhibitor SRX3262 overcomes Ibrutinib resistance in mantle cell lymphoma.

Pal D, Vann KR, Joshi S, Sahar NE, Morales GA, El-Gamal D, Kutateladze TG, Durden DL. Pal D, et al. iScience. 2021 Jul 30;24(9):102931. doi: 10.1016/j.isci.2021.102931. eCollection 2021 Sep 24. iScience. 2021. PMID: 34557659 Free PMC article.

7

Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma.

Vann KR, Pal D, Smith AL, Sahar NE, Krishnaiah M, El-Gamal D, Kutateladze TG. Vann KR, et al. Mol Biomed. 2022 Jan 15;3(1):2. doi: 10.1186/s43556-021-00066-9. Mol Biomed. 2022. PMID: 35031886 Free PMC article.

8

Insect cell expression and purification of recombinant SARS-COV-2 spike proteins that demonstrate ACE2 binding.

Struble LR, Smith AL, Lutz WE, Grubbs G, Sagar S, Bayles KW, Radhakrishnan P, Khurana S, El-Gamal D, Borgstahl GEO. Struble LR, et al. Protein Sci. 2022 May;31(5):e4300. doi: 10.1002/pro.4300. Protein Sci. 2022. PMID: 35481636 Free PMC article.

9

Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.

Vann KR, Acharya A, Jang SM, Lachance C, Zandian M, Holt TA, Smith AL, Pandey K, Durden DL, El-Gamal D, Côté J, Byrareddy SN, Kutateladze TG. Vann KR, et al. Structure. 2022 Sep 1;30(9):1224-1232.e5. doi: 10.1016/j.str.2022.05.020. Epub 2022 Jun 17. Structure. 2022. PMID: 35716662 Free PMC article.

10

Perturbation of the gut microbiome and association with outcomes following autologous stem cell transplantation in patients with multiple myeloma.

D'Angelo C, Sudakaran S, Asimakopoulos F, Hematti P, El-Gamal D, Safdar N, Callander N. D'Angelo C, et al. Leuk Lymphoma. 2023 Jan;64(1):87-97. doi: 10.1080/10428194.2022.2131410. Epub 2022 Oct 11. Leuk Lymphoma. 2023. PMID: 36218226 Free PMC article.

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