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Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2).
Liatsikos K, Hyder-Wright A, Pojar S, Chen T, Wang D, Davies K, Myerscough C, Reine J, Robinson RE, Urban B, Mitsi E, Solorzano C, Gordon SB, Quinn A, Pan K, Anderson AS, Theilacker C, Begier E, Gessner BD, Collins A, Ferreira DM; PNEUMO 2 study group. Liatsikos K, et al. Among authors: pojar s. BMJ Open. 2022 Jul 7;12(7):e062109. doi: 10.1136/bmjopen-2022-062109. BMJ Open. 2022. PMID: 35798520 Free PMC article.
Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage.
Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM. Pennington SH, et al. Among authors: pojar s. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1523-1531. doi: 10.1164/rccm.201512-2467OC. Am J Respir Crit Care Med. 2016. PMID: 27403678 Free PMC article.
Hands are vehicles for transmission of Streptococcus pneumoniae in novel controlled human infection study.
Connor V, German E, Pojar S, Mitsi E, Hales C, Nikolaou E, Hyder-Wright A, Adler H, Zaidi S, Hill H, Jochems SP, Burhan H, French N, Tobery T, Rylance J, Ferreira DM. Connor V, et al. Among authors: pojar s. Eur Respir J. 2018 Oct 10;52(4):1800599. doi: 10.1183/13993003.00599-2018. Print 2018 Oct. Eur Respir J. 2018. PMID: 30305331 Free article. No abstract available.
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
Jochems SP, Marcon F, Carniel BF, Holloway M, Mitsi E, Smith E, Gritzfeld JF, Solórzano C, Reiné J, Pojar S, Nikolaou E, German EL, Hyder-Wright A, Hill H, Hales C, de Steenhuijsen Piters WAA, Bogaert D, Adler H, Zaidi S, Connor V, Gordon SB, Rylance J, Nakaya HI, Ferreira DM. Jochems SP, et al. Among authors: pojar s. Nat Immunol. 2018 Dec;19(12):1299-1308. doi: 10.1038/s41590-018-0231-y. Epub 2018 Oct 29. Nat Immunol. 2018. PMID: 30374129 Free PMC article. Clinical Trial.
Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010-2017.
Adler H, Nikolaou E, Gould K, Hinds J, Collins AM, Connor V, Hales C, Hill H, Hyder-Wright AD, Zaidi SR, German EL, Gritzfeld JF, Mitsi E, Pojar S, Gordon SB, Roberts AP, Rylance J, Ferreira DM. Adler H, et al. Among authors: pojar s. J Infect Dis. 2019 May 24;219(12):1989-1993. doi: 10.1093/infdis/jiz034. J Infect Dis. 2019. PMID: 30690468 Free PMC article.
Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine.
de Steenhuijsen Piters WAA, Jochems SP, Mitsi E, Rylance J, Pojar S, Nikolaou E, German EL, Holloway M, Carniel BF, Chu MLJN, Arp K, Sanders EAM, Ferreira DM, Bogaert D. de Steenhuijsen Piters WAA, et al. Among authors: pojar s. Nat Commun. 2019 Jul 5;10(1):2981. doi: 10.1038/s41467-019-10814-9. Nat Commun. 2019. PMID: 31278315 Free PMC article.
Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization.
Jochems SP, de Ruiter K, Solórzano C, Voskamp A, Mitsi E, Nikolaou E, Carniel BF, Pojar S, German EL, Reiné J, Soares-Schanoski A, Hill H, Robinson R, Hyder-Wright AD, Weight CM, Durrenberger PF, Heyderman RS, Gordon SB, Smits HH, Urban BC, Rylance J, Collins AM, Wilkie MD, Lazarova L, Leong SC, Yazdanbakhsh M, Ferreira DM. Jochems SP, et al. Among authors: pojar s. J Clin Invest. 2019 Jul 30;129(10):4523-4538. doi: 10.1172/JCI128865. J Clin Invest. 2019. PMID: 31361601 Free PMC article. Clinical Trial.
Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens.
Mitsi E, Carniel B, Reiné J, Rylance J, Zaidi S, Soares-Schanoski A, Connor V, Collins AM, Schlitzer A, Nikolaou E, Solórzano C, Pojar S, Hill H, Hyder-Wright AD, Jambo KC, Oggioni MR, De Ste Croix M, Gordon SB, Jochems SP, Ferreira DM. Mitsi E, et al. Among authors: pojar s. Am J Respir Crit Care Med. 2020 Feb 1;201(3):335-347. doi: 10.1164/rccm.201903-0607OC. Am J Respir Crit Care Med. 2020. PMID: 31626559 Free PMC article.
27 results