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Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression.
Solimando AG, Da Vià MC, Leone P, Borrelli P, Croci GA, Tabares P, Brandl A, Di Lernia G, Bianchi FP, Tafuri S, Steinbrunn T, Balduini A, Melaccio A, De Summa S, Argentiero A, Rauert-Wunderlich H, Frassanito MA, Ditonno P, Henke E, Klapper W, Ria R, Terragna C, Rasche L, Rosenwald A, Kortüm MK, Cavo M, Ribatti D, Racanelli V, Einsele H, Vacca A, Beilhack A. Solimando AG, et al. Among authors: steinbrunn t. Haematologica. 2021 Jul 1;106(7):1943-1956. doi: 10.3324/haematol.2019.239913. Haematologica. 2021. PMID: 32354870 Free PMC article.
RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS.
Seibold M, Stühmer T, Kremer N, Mottok A, Scholz CJ, Schlosser A, Leich E, Holzgrabe U, Brünnert D, Barrio S, Kortüm MK, Solimando AG, Chatterjee M, Einsele H, Rosenwald A, Bargou RC, Steinbrunn T. Seibold M, et al. Among authors: steinbrunn t. Haematologica. 2020 Sep 1;105(9):2316-2326. doi: 10.3324/haematol.2019.223024. Haematologica. 2020. PMID: 33054056 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 31601693
Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines.
Weißbach S, Heredia-Guerrero SC, Barnsteiner S, Großhans L, Bodem J, Starz H, Langer C, Appenzeller S, Knop S, Steinbrunn T, Rost S, Einsele H, Bargou RC, Rosenwald A, Stühmer T, Leich E. Weißbach S, et al. Among authors: steinbrunn t. Cancers (Basel). 2020 Feb 16;12(2):455. doi: 10.3390/cancers12020455. Cancers (Basel). 2020. PMID: 32079091 Free PMC article.
PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.
Hofmann C, Stühmer T, Schmiedl N, Wetzker R, Mottok A, Rosenwald A, Langer C, Zovko J, Chatterjee M, Einsele H, Bargou RC, Steinbrunn T. Hofmann C, et al. Among authors: steinbrunn t. Br J Haematol. 2014 Aug;166(4):529-39. doi: 10.1111/bjh.12920. Epub 2014 Apr 26. Br J Haematol. 2014. PMID: 24766330 Free article.
Multiple myeloma is affected by multiple and heterogeneous somatic mutations in adhesion- and receptor tyrosine kinase signaling molecules.
Leich E, Weißbach S, Klein HU, Grieb T, Pischimarov J, Stühmer T, Chatterjee M, Steinbrunn T, Langer C, Eilers M, Knop S, Einsele H, Bargou R, Rosenwald A. Leich E, et al. Among authors: steinbrunn t. Blood Cancer J. 2013 Feb 8;3(2):e102. doi: 10.1038/bcj.2012.47. Blood Cancer J. 2013. PMID: 23396385 Free PMC article.
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