Lei X - Search Results

1

Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling.

Aguirre RS, Kulkarni A, Becker MW, Lei X, Sarkar S, Ramanadham S, Phelps EA, Nakayasu ES, Sims EK, Mirmira RG. Aguirre RS, et al. Among authors: lei x. Mol Metab. 2022 Sep;63:101545. doi: 10.1016/j.molmet.2022.101545. Epub 2022 Jul 8. Mol Metab. 2022. PMID: 35817393 Free PMC article. Review.

2

Protease inhibitors used in the treatment of HIV+ induce beta-cell apoptosis via the mitochondrial pathway and compromise insulin secretion.

Zhang S, Carper MJ, Lei X, Cade WT, Yarasheski KE, Ramanadham S. Zhang S, et al. Among authors: lei x. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E925-35. doi: 10.1152/ajpendo.90445.2008. Epub 2009 Feb 10. Am J Physiol Endocrinol Metab. 2009. PMID: 19208856 Free PMC article.

3

Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death.

Lei X, Barbour SE, Ramanadham S. Lei X, et al. Biochimie. 2010 Jun;92(6):627-37. doi: 10.1016/j.biochi.2010.01.005. Epub 2010 Jan 18. Biochimie. 2010. PMID: 20083151 Free PMC article. Review.

4

A link between endoplasmic reticulum stress-induced β-cell apoptosis and the group VIA Ca2+-independent phospholipase A2 (iPLA2β).

Lei X, Zhang S, Emani B, Barbour SE, Ramanadham S. Lei X, et al. Diabetes Obes Metab. 2010 Oct;12 Suppl 2(0 2):93-8. doi: 10.1111/j.1463-1326.2010.01270.x. Diabetes Obes Metab. 2010. PMID: 21029305 Free PMC article. Review.

5

Role of calcium-independent phospholipase A(2)β in human pancreatic islet β-cell apoptosis.

Lei X, Zhang S, Bohrer A, Barbour SE, Ramanadham S. Lei X, et al. Am J Physiol Endocrinol Metab. 2012 Dec 1;303(11):E1386-95. doi: 10.1152/ajpendo.00234.2012. Epub 2012 Oct 16. Am J Physiol Endocrinol Metab. 2012. PMID: 23074238 Free PMC article.

6

Genetic modulation of islet β-cell iPLA₂β expression provides evidence for its impact on β-cell apoptosis and autophagy.

Lei X, Bone RN, Ali T, Wohltmann M, Gai Y, Goodwin KJ, Bohrer AE, Turk J, Ramanadham S. Lei X, et al. Islets. 2013 Jan-Feb;5(1):29-44. doi: 10.4161/isl.23758. Epub 2013 Jan 1. Islets. 2013. PMID: 23411472 Free PMC article.

7

Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+/Ins2)-derived β-cells.

Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM. Mitchell T, et al. Among authors: lei x. Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E585-99. doi: 10.1152/ajpendo.00093.2013. Epub 2013 Jul 2. Am J Physiol Endocrinol Metab. 2013. PMID: 23820623 Free PMC article.

8

Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development.

Lei X, Bone RN, Ali T, Zhang S, Bohrer A, Tse HM, Bidasee KR, Ramanadham S. Lei X, et al. Endocrinology. 2014 Sep;155(9):3352-64. doi: 10.1210/en.2013-2134. Epub 2014 Jul 8. Endocrinology. 2014. PMID: 25004092 Free PMC article.

9

Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice.

Bone RN, Gai Y, Magrioti V, Kokotou MG, Ali T, Lei X, Tse HM, Kokotos G, Ramanadham S. Bone RN, et al. Among authors: lei x. Diabetes. 2015 Feb;64(2):541-54. doi: 10.2337/db14-0097. Epub 2014 Sep 11. Diabetes. 2015. PMID: 25213337 Free PMC article.

10

Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.

Barbour SE, Nguyen PT, Park M, Emani B, Lei X, Kambalapalli M, Shultz JC, Wijesinghe D, Chalfant CE, Ramanadham S. Barbour SE, et al. Among authors: lei x. J Biol Chem. 2015 Apr 24;290(17):11021-31. doi: 10.1074/jbc.M115.648956. Epub 2015 Mar 11. J Biol Chem. 2015. PMID: 25762722 Free PMC article.

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