Chin YKY - Search Results

1

The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAF^V600E.

Moral-Sanz J, Fernandez-Rojo MA, Colmenarejo G, Kurdyukov S, Brust A, Ragnarsson L, Andersson Å, Vila SF, Cabezas-Sainz P, Wilhelm P, Vela-Sebastián A, Fernández-Carrasco I, Chin YKY, López-Mancheño Y, Smallwood TB, Clark RJ, Fry BG, King GF, Ramm GA, Alewood PF, Lewis RJ, Mulvenna JP, Boyle GM, Sanchez LE, Neely GG, Miles JJ, Ikonomopoulou MP. Moral-Sanz J, et al. Among authors: chin yky. Br J Pharmacol. 2022 Oct;179(20):4878-4896. doi: 10.1111/bph.15923. Epub 2022 Jul 29. Br J Pharmacol. 2022. PMID: 35818835 Free article.

2

Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus.

Touchard A, Brust A, Cardoso FC, Chin YK, Herzig V, Jin AH, Dejean A, Alewood PF, King GF, Orivel J, Escoubas P. Touchard A, et al. Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2553-2562. doi: 10.1016/j.bbagen.2016.07.027. Epub 2016 Jul 28. Biochim Biophys Acta. 2016. PMID: 27474999

3

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF. Chassagnon IR, et al. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320941 Free PMC article.

4

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. Wingerd JS, et al. Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0. Sci Rep. 2017. PMID: 28428547 Free PMC article.

5

Structural basis for the modulation of voltage-gated sodium channels by animal toxins.

Shen H, Li Z, Jiang Y, Pan X, Wu J, Cristofori-Armstrong B, Smith JJ, Chin YKY, Lei J, Zhou Q, King GF, Yan N. Shen H, et al. Among authors: chin yky. Science. 2018 Oct 19;362(6412):eaau2596. doi: 10.1126/science.aau2596. Epub 2018 Jul 26. Science. 2018. PMID: 30049784

6

PHAB toxins: a unique family of predatory sea anemone toxins evolving via intra-gene concerted evolution defines a new peptide fold.

Madio B, Peigneur S, Chin YKY, Hamilton BR, Henriques ST, Smith JJ, Cristofori-Armstrong B, Dekan Z, Boughton BA, Alewood PF, Tytgat J, King GF, Undheim EAB. Madio B, et al. Among authors: chin yky. Cell Mol Life Sci. 2018 Dec;75(24):4511-4524. doi: 10.1007/s00018-018-2897-6. Epub 2018 Aug 14. Cell Mol Life Sci. 2018. PMID: 30109357 Free PMC article.

7

Novel venom-derived inhibitors of the human EAG channel, a putative antiepileptic drug target.

Ma L, Chin YKY, Dekan Z, Herzig V, Chow CY, Heighway J, Lam SW, Guillemin GJ, Alewood PF, King GF. Ma L, et al. Among authors: chin yky. Biochem Pharmacol. 2018 Dec;158:60-72. doi: 10.1016/j.bcp.2018.08.038. Epub 2018 Aug 25. Biochem Pharmacol. 2018. PMID: 30149017

8

Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides.

Herzig V, de Araujo AD, Greenwood KP, Chin YK, Windley MJ, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson GM, Alewood PF, King GF. Herzig V, et al. Biomedicines. 2018 Aug 28;6(3):90. doi: 10.3390/biomedicines6030090. Biomedicines. 2018. PMID: 30154370 Free PMC article.

9

The unusual conformation of cross-strand disulfide bonds is critical to the stability of β-hairpin peptides.

Deplazes E, Chin YK, King GF, Mancera RL. Deplazes E, et al. Proteins. 2020 Mar;88(3):485-502. doi: 10.1002/prot.25828. Epub 2019 Oct 16. Proteins. 2020. PMID: 31589791

10

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom.

Luna-Ramirez K, Csoti A, McArthur JR, Chin YKY, Anangi R, Najera RDC, Possani LD, King GF, Panyi G, Yu H, Adams DJ, Finol-Urdaneta RK. Luna-Ramirez K, et al. Among authors: chin yky. Biochem Pharmacol. 2020 Apr;174:113782. doi: 10.1016/j.bcp.2019.113782. Epub 2019 Dec 25. Biochem Pharmacol. 2020. PMID: 31881193

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