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TFAP2B Haploinsufficiency Impacts Gastrointestinal Function and Leads to Pediatric Intestinal Pseudo-obstruction.
Zada A, Kuil LE, de Graaf BM, Kakiailatu N, Windster JD, Brooks AS, van Slegtenhorst M, de Koning B, Wijnen RMH, Melotte V, Hofstra RMW, Brosens E, Alves MM. Zada A, et al. Among authors: melotte v. Front Cell Dev Biol. 2022 Jul 8;10:901824. doi: 10.3389/fcell.2022.901824. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35874825 Free PMC article.
NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.
Vaes N, Lentjes MHFM, Gijbels MJ, Rademakers G, Daenen KL, Boesmans W, Wouters KAD, Geuzens A, Qu X, Steinbusch HPJ, Rutten BPF, Baldwin SH, Sharkey KA, Hofstra RMW, van Engeland M, Vanden Berghe P, Melotte V. Vaes N, et al. Among authors: melotte v. Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13095. Epub 2017 May 19. Neurogastroenterol Motil. 2017. PMID: 28524415
Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2.
Vaes N, Schonkeren SL, Rademakers G, Holland AM, Koch A, Gijbels MJ, Keulers TG, de Wit M, Moonen L, Van der Meer JRM, van den Boezem E, Wolfs TGAM, Threadgill DW, Demmers J, Fijneman RJA, Jimenez CR, Vanden Berghe P, Smits KM, Rouschop KMA, Boesmans W, Hofstra RMW, Melotte V. Vaes N, et al. Among authors: melotte v. EMBO Rep. 2021 Jun 4;22(6):e51913. doi: 10.15252/embr.202051913. Epub 2021 Apr 23. EMBO Rep. 2021. PMID: 33890711 Free PMC article.
Intestinal multicellular organoids to study colorectal cancer.
Idris M, Alves MM, Hofstra RMW, Mahe MM, Melotte V. Idris M, et al. Among authors: melotte v. Biochim Biophys Acta Rev Cancer. 2021 Dec;1876(2):188586. doi: 10.1016/j.bbcan.2021.188586. Epub 2021 Jun 30. Biochim Biophys Acta Rev Cancer. 2021. PMID: 34216725 Free article. Review.
Nerves in gastrointestinal cancer: from mechanism to modulations.
Vaes N, Idris M, Boesmans W, Alves MM, Melotte V. Vaes N, et al. Among authors: melotte v. Nat Rev Gastroenterol Hepatol. 2022 Dec;19(12):768-784. doi: 10.1038/s41575-022-00669-9. Epub 2022 Sep 2. Nat Rev Gastroenterol Hepatol. 2022. PMID: 36056202 Review.
59 results