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A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH. Galaj E, et al. Among authors: klein b. Neuropsychopharmacology. 2022 Dec;47(13):2309-2318. doi: 10.1038/s41386-022-01379-1. Epub 2022 Jul 25. Neuropsychopharmacology. 2022. PMID: 35879349 Free PMC article.
Dopamine D3/D2 Receptor Ligands Based on Cariprazine for the Treatment of Psychostimulant Use Disorders That May Be Dual Diagnosed with Affective Disorders.
Gogarnoiu ES, Vogt CD, Sanchez J, Bonifazi A, Saab E, Shaik AB, Soler-Cedeño O, Bi GH, Klein B, Xi ZX, Lane JR, Newman AH. Gogarnoiu ES, et al. Among authors: klein b. J Med Chem. 2023 Feb 9;66(3):1809-1834. doi: 10.1021/acs.jmedchem.2c01624. Epub 2023 Jan 20. J Med Chem. 2023. PMID: 36661568 Free PMC article.
PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice.
Xi ZX, Hempel B, Crissman M, Pari S, Klein B, Bi GH, Alton H. Xi ZX, et al. Among authors: klein b. Res Sq [Preprint]. 2023 Mar 2:rs.3.rs-2614714. doi: 10.21203/rs.3.rs-2614714/v1. Res Sq. 2023. Update in: Mol Psychiatry. 2023 Oct;28(10):4203-4214. doi: 10.1038/s41380-023-02182-0 PMID: 36909477 Free PMC article. Updated. Preprint.
Modifications to 1-(4-(2-Bis(4-fluorophenyl)methyl)sulfinyl)alkyl Alicyclic Amines That Improve Metabolic Stability and Retain an Atypical DAT Inhibitor Profile.
Okorom AV, Camacho-Hernandez GA, Salomon K, Lee KH, Ku TC, Cao J, Won SJ, Friedman J, Lam J, Paule J, Rais R, Klein B, Xi ZX, Shi L, Loland CJ, Newman AH. Okorom AV, et al. Among authors: klein b. J Med Chem. 2024 Jan 11;67(1):709-727. doi: 10.1021/acs.jmedchem.3c02037. Epub 2023 Dec 20. J Med Chem. 2024. PMID: 38117239
Safety and tolerability of ubrogepant for the acute treatment of migraine in participants taking atogepant for the preventive treatment of episodic migraine: Results from the TANDEM study.
Ailani J, Lipton RB, Blumenfeld AM, Mechtler L, Klein BC, He MY, Smith JH, Trugman JM, de Abreu Ferreira R, Brand-Schieber E. Ailani J, et al. Among authors: klein bc. Headache. 2024 Nov 21. doi: 10.1111/head.14871. Online ahead of print. Headache. 2024. PMID: 39569702
Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes.
Roshandel D, Spiliopoulou A, McGurnaghan SJ, Iakovliev A, Lipschutz D, Hayward C, Bull SB, Klein BEK, Lee KE, Kinney GL, Rewers M, Costacou T, Miller RG, McKeigue PM, Paterson AD, Colhoun HM. Roshandel D, et al. Among authors: klein bek. Diabetes. 2024 Nov 18:db240340. doi: 10.2337/db24-0340. Online ahead of print. Diabetes. 2024. PMID: 39556808
2,746 results