Orlicky S - Search Results

1

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.

Szychowski J, Papp R, Dietrich E, Liu B, Vallée F, Leclaire ME, Fourtounis J, Martino G, Perryman AL, Pau V, Yin SY, Mader P, Roulston A, Truchon JF, Marshall CG, Diallo M, Duffy NM, Stocco R, Godbout C, Bonneau-Fortin A, Kryczka R, Bhaskaran V, Mao D, Orlicky S, Beaulieu P, Turcotte P, Kurinov I, Sicheri F, Mamane Y, Gallant M, Black WC. Szychowski J, et al. Among authors: orlicky s. J Med Chem. 2022 Aug 11;65(15):10251-10284. doi: 10.1021/acs.jmedchem.2c00552. Epub 2022 Jul 26. J Med Chem. 2022. PMID: 35880755 Free PMC article.

2

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.

Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M. Nash P, et al. Among authors: orlicky s. Nature. 2001 Nov 29;414(6863):514-21. doi: 10.1038/35107009. Nature. 2001. PMID: 11734846

3

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Orlicky S, et al. Cell. 2003 Jan 24;112(2):243-56. doi: 10.1016/s0092-8674(03)00034-5. Cell. 2003. PMID: 12553912 Free article.

4

Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.

Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M. Tang X, et al. Among authors: orlicky s. Methods Enzymol. 2005;399:433-58. doi: 10.1016/S0076-6879(05)99030-7. Methods Enzymol. 2005. PMID: 16338374

5

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M. Tang X, et al. Among authors: orlicky s. Cell. 2007 Jun 15;129(6):1165-76. doi: 10.1016/j.cell.2007.04.042. Cell. 2007. PMID: 17574027 Free article.

6

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F. Mao DY, et al. Among authors: orlicky s. Mol Cell. 2008 Oct 24;32(2):259-75. doi: 10.1016/j.molcel.2008.10.002. Mol Cell. 2008. PMID: 18951093 Free PMC article.

7

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.

Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Mittag T, et al. Among authors: orlicky s. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17772-7. doi: 10.1073/pnas.0809222105. Epub 2008 Nov 13. Proc Natl Acad Sci U S A. 2008. PMID: 19008353 Free PMC article.

8

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase.

Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Mittag T, et al. Among authors: orlicky s. Structure. 2010 Mar 14;18(4):494-506. doi: 10.1016/j.str.2010.01.020. Structure. 2010. PMID: 20399186 Free PMC article.

9

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.

Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. Orlicky S, et al. Nat Biotechnol. 2010 Jul;28(7):733-7. doi: 10.1038/nbt.1646. Epub 2010 Jun 27. Nat Biotechnol. 2010. PMID: 20581844 Free PMC article.

10

OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.

Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, Durocher D. Juang YC, et al. Among authors: orlicky s. Mol Cell. 2012 Feb 10;45(3):384-97. doi: 10.1016/j.molcel.2012.01.011. Mol Cell. 2012. PMID: 22325355 Free PMC article.

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