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Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.
Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper TS, Lieberman J, Liu X. Deng W, et al. Among authors: wu z. Nature. 2022 Feb;602(7897):496-502. doi: 10.1038/s41586-021-04384-4. Epub 2022 Feb 2. Nature. 2022. PMID: 35110732 Free PMC article.
Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2.
Bai Y, Min R, Chen P, Mei S, Deng F, Zheng Z, Jiang C, Miao R, Wu Z, Zhang P, Pan Y, Lieberman J, Liu X. Bai Y, et al. Among authors: wu z. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2306399120. doi: 10.1073/pnas.2306399120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487070 Free PMC article.
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