Kumar R - Search Results

1

The activin receptor ligand trap ActRIIB:ALK4-Fc ameliorates cardiomyopathy induced by neuromuscular disease and diabetes.

Li J, Fredericks M, Tang M, Cannell M, Joshi S, Kumar R, Andre P, Suragani RNVS. Li J, et al. Among authors: kumar r. FEBS Lett. 2022 Dec;596(24):3145-3158. doi: 10.1002/1873-3468.14464. Epub 2022 Aug 29. FEBS Lett. 2022. PMID: 35920165 Free article.

2

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.

Suragani RN, Cadena SM, Cawley SM, Sako D, Mitchell D, Li R, Davies MV, Alexander MJ, Devine M, Loveday KS, Underwood KW, Grinberg AV, Quisel JD, Chopra R, Pearsall RS, Seehra J, Kumar R. Suragani RN, et al. Among authors: kumar r. Nat Med. 2014 Apr;20(4):408-14. doi: 10.1038/nm.3512. Epub 2014 Mar 23. Nat Med. 2014. PMID: 24658078

3

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia.

Suragani RN, Cawley SM, Li R, Wallner S, Alexander MJ, Mulivor AW, Gardenghi S, Rivella S, Grinberg AV, Pearsall RS, Kumar R. Suragani RN, et al. Among authors: kumar r. Blood. 2014 Jun 19;123(25):3864-72. doi: 10.1182/blood-2013-06-511238. Epub 2014 May 2. Blood. 2014. PMID: 24795345 Free PMC article.

4

Smad2/3-pathway ligand trap luspatercept enhances erythroid differentiation in murine β-thalassaemia by increasing GATA-1 availability.

Martinez PA, Li R, Ramanathan HN, Bhasin M, Pearsall RS, Kumar R, Suragani RNVS. Martinez PA, et al. Among authors: kumar r. J Cell Mol Med. 2020 Jun;24(11):6162-6177. doi: 10.1111/jcmm.15243. Epub 2020 Apr 29. J Cell Mol Med. 2020. PMID: 32351032 Free PMC article.

5

ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension.

Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. Yung LM, et al. Among authors: kumar r. Sci Transl Med. 2020 May 13;12(543):eaaz5660. doi: 10.1126/scitranslmed.aaz5660. Sci Transl Med. 2020. PMID: 32404506 Free PMC article.

6

ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders.

Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN. Li J, et al. Among authors: kumar r. J Clin Invest. 2021 Feb 15;131(4):e138634. doi: 10.1172/JCI138634. J Clin Invest. 2021. PMID: 33586684 Free PMC article.

7

Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily.

Kumar R, Grinberg AV, Li H, Kuo TH, Sako D, Krishnan L, Liharska K, Li J, Grenha R, Maguire MC, Briscoe SD, Pearsall RS, Herrin BR, Suragani RNVS, Castonguay R. Kumar R, et al. Sci Rep. 2021 Sep 15;11(1):18341. doi: 10.1038/s41598-021-97203-9. Sci Rep. 2021. PMID: 34526551 Free PMC article.

8

Therapeutic Approaches for Treating Pulmonary Arterial Hypertension by Correcting Imbalanced TGF-β Superfamily Signaling.

Andre P, Joshi SR, Briscoe SD, Alexander MJ, Li G, Kumar R. Andre P, et al. Among authors: kumar r. Front Med (Lausanne). 2022 Jan 24;8:814222. doi: 10.3389/fmed.2021.814222. eCollection 2021. Front Med (Lausanne). 2022. PMID: 35141256 Free PMC article. Review.

9

Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.

Joshi SR, Liu J, Bloom T, Karaca Atabay E, Kuo TH, Lee M, Belcheva E, Spaits M, Grenha R, Maguire MC, Frost JL, Wang K, Briscoe SD, Alexander MJ, Herrin BR, Castonguay R, Pearsall RS, Andre P, Yu PB, Kumar R, Li G. Joshi SR, et al. Among authors: kumar r. Sci Rep. 2022 May 12;12(1):7803. doi: 10.1038/s41598-022-11435-x. Sci Rep. 2022. PMID: 35551212 Free PMC article.

10

Sotatercept analog improves cardiopulmonary remodeling and pulmonary hypertension in experimental left heart failure.

Joshi SR, Atabay EK, Liu J, Ding Y, Briscoe SD, Alexander MJ, Andre P, Kumar R, Li G. Joshi SR, et al. Among authors: kumar r. Front Cardiovasc Med. 2023 Feb 23;10:1064290. doi: 10.3389/fcvm.2023.1064290. eCollection 2023. Front Cardiovasc Med. 2023. PMID: 36910526 Free PMC article.

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