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Coronaviruses exploit a host cysteine-aspartic protease for replication.
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Chu H, et al. Among authors: luo c. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. Nature. 2022. PMID: 35922005
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
To KK, Tsang OT, Leung WS, Tam AR, Wu TC, Lung DC, Yip CC, Cai JP, Chan JM, Chik TS, Lau DP, Choi CY, Chen LL, Chan WM, Chan KH, Ip JD, Ng AC, Poon RW, Luo CT, Cheng VC, Chan JF, Hung IF, Chen Z, Chen H, Yuen KY. To KK, et al. Lancet Infect Dis. 2020 May;20(5):565-574. doi: 10.1016/S1473-3099(20)30196-1. Epub 2020 Mar 23. Lancet Infect Dis. 2020. PMID: 32213337 Free PMC article.
Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility.
Chan JF, Zhang AJ, Yuan S, Poon VK, Chan CC, Lee AC, Chan WM, Fan Z, Tsoi HW, Wen L, Liang R, Cao J, Chen Y, Tang K, Luo C, Cai JP, Kok KH, Chu H, Chan KH, Sridhar S, Chen Z, Chen H, To KK, Yuen KY. Chan JF, et al. Among authors: luo c. Clin Infect Dis. 2020 Dec 3;71(9):2428-2446. doi: 10.1093/cid/ciaa325. Clin Infect Dis. 2020. PMID: 32215622 Free PMC article.
Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19).
Chan JF, Yuan S, Zhang AJ, Poon VK, Chan CC, Lee AC, Fan Z, Li C, Liang R, Cao J, Tang K, Luo C, Cheng VC, Cai JP, Chu H, Chan KH, To KK, Sridhar S, Yuen KY. Chan JF, et al. Among authors: luo c. Clin Infect Dis. 2020 Nov 19;71(16):2139-2149. doi: 10.1093/cid/ciaa644. Clin Infect Dis. 2020. PMID: 32472679 Free PMC article.
Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study.
To KK, Cheng VC, Cai JP, Chan KH, Chen LL, Wong LH, Choi CY, Fong CH, Ng AC, Lu L, Luo CT, Situ J, Chung TW, Wong SC, Kwan GS, Sridhar S, Chan JF, Fan CY, Chuang VWM, Kok KH, Hung IF, Yuen KY. To KK, et al. Lancet Microbe. 2020 Jul;1(3):e111-e118. doi: 10.1016/S2666-5247(20)30053-7. Epub 2020 Jun 3. Lancet Microbe. 2020. PMID: 33230504 Free PMC article.
In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor.
Wen L, Tang K, Chik KK, Chan CC, Tsang JO, Liang R, Cao J, Huang Y, Luo C, Cai JP, Ye ZW, Yin F, Chu H, Jin DY, Yuen KY, Yuan S, Chan JF. Wen L, et al. Among authors: luo c. Int J Biol Sci. 2021 Apr 10;17(6):1555-1564. doi: 10.7150/ijbs.59191. eCollection 2021. Int J Biol Sci. 2021. PMID: 33907519 Free PMC article.
Low Environmental Temperature Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Golden Syrian Hamsters.
Chan JFW, Poon VKM, Chan CCS, Chik KKH, Tsang JOL, Zou Z, Chan CCY, Lee ACY, Li C, Liang R, Cao J, Tang K, Yuen TTT, Hu B, Huang X, Chai Y, Shuai H, Luo C, Cai JP, Chan KH, Sridhar S, Yin F, Kok KH, Chu H, Zhang AJ, Yuan S, Yuen KY. Chan JFW, et al. Among authors: luo c. Clin Infect Dis. 2022 Aug 24;75(1):e1101-e1111. doi: 10.1093/cid/ciab817. Clin Infect Dis. 2022. PMID: 34536277
SARS-CoV-2 exploits host DGAT and ADRP for efficient replication.
Yuan S, Yan B, Cao J, Ye ZW, Liang R, Tang K, Luo C, Cai J, Chu H, Chung TW, To KK, Hung IF, Jin DY, Chan JF, Yuen KY. Yuan S, et al. Among authors: luo c. Cell Discov. 2021 Oct 26;7(1):100. doi: 10.1038/s41421-021-00338-2. Cell Discov. 2021. PMID: 34702802 Free PMC article.
Probable Animal-to-Human Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant AY.127 Causing a Pet Shop-Related Coronavirus Disease 2019 (COVID-19) Outbreak in Hong Kong.
Chan JFW, Siu GKH, Yuan S, Ip JD, Cai JP, Chu AWH, Chan WM, Abdullah SMU, Luo C, Chan BPC, Yuen TTT, Chen LL, Chik KKH, Liang R, Cao H, Poon VKM, Chan CCS, Leung KH, Tam AR, Tsang OTY, Chan JMC, To WK, Lam BHS, Lee LK, Lo HWH, Wong ITF, Leung JSL, Wong EYK, Chu H, Yip CCY, Cheng VCC, Chan KH, Tse H, Lung DC, Ng KHL, Au AKW, Hung IFN, Yuen KY, To KKW. Chan JFW, et al. Among authors: luo c. Clin Infect Dis. 2022 Aug 24;75(1):e76-e81. doi: 10.1093/cid/ciac171. Clin Infect Dis. 2022. PMID: 35234870 Free PMC article.
8,422 results