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Coronaviruses exploit a host cysteine-aspartic protease for replication.
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Chu H, et al. Among authors: poon vk. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. Nature. 2022. PMID: 35922005
Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis.
Zhou J, Chu H, Li C, Wong BH, Cheng ZS, Poon VK, Sun T, Lau CC, Wong KK, Chan JY, Chan JF, To KK, Chan KH, Zheng BJ, Yuen KY. Zhou J, et al. Among authors: poon vk. J Infect Dis. 2014 May 1;209(9):1331-42. doi: 10.1093/infdis/jit504. Epub 2013 Sep 24. J Infect Dis. 2014. PMID: 24065148 Free PMC article.
Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons.
Chan JF, Zhang AJ, Chan CC, Yip CC, Mak WW, Zhu H, Poon VK, Tee KM, Zhu Z, Cai JP, Tsang JO, Chik KK, Yin F, Chan KH, Kok KH, Jin DY, Au-Yeung RK, Yuen KY. Chan JF, et al. Among authors: poon vk. EBioMedicine. 2016 Dec;14:112-122. doi: 10.1016/j.ebiom.2016.11.017. Epub 2016 Nov 12. EBioMedicine. 2016. PMID: 27884655 Free PMC article.
Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus.
Chan JF, Yip CC, Tee KM, Zhu Z, Tsang JO, Chik KK, Tsang TG, Chan CC, Poon VK, Sridhar S, Yin F, Hung IF, Chau SK, Zhang AJ, Chan KH, Yuen KY. Chan JF, et al. Among authors: poon vk. Trop Med Int Health. 2017 May;22(5):594-603. doi: 10.1111/tmi.12857. Epub 2017 Mar 16. Trop Med Int Health. 2017. PMID: 28214373 Free article.
Structure-based discovery of clinically approved drugs as Zika virus NS2B-NS3 protease inhibitors that potently inhibit Zika virus infection in vitro and in vivo.
Yuan S, Chan JF, den-Haan H, Chik KK, Zhang AJ, Chan CC, Poon VK, Yip CC, Mak WW, Zhu Z, Zou Z, Tee KM, Cai JP, Chan KH, de la Peña J, Pérez-Sánchez H, Cerón-Carrasco JP, Yuen KY. Yuan S, et al. Among authors: poon vk. Antiviral Res. 2017 Sep;145:33-43. doi: 10.1016/j.antiviral.2017.07.007. Epub 2017 Jul 14. Antiviral Res. 2017. PMID: 28712942
Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.
Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY. Zhou J, et al. Among authors: poon vk. Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov. Sci Adv. 2017. PMID: 29152574 Free PMC article.
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