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Page 1
The druggability of SH2 domains unmasked.
Hantschel O. Hantschel O. Nat Chem Biol. 2024 Mar;20(3):271-272. doi: 10.1038/s41589-024-01557-w. Nat Chem Biol. 2024. PMID: 38361089 No abstract available.
Bcr-Abl: one kinase, two isoforms, two diseases.
Reckel S, Hantschel O. Reckel S, et al. Among authors: hantschel o. Oncotarget. 2017 Sep 14;8(45):78257-78258. doi: 10.18632/oncotarget.20874. eCollection 2017 Oct 3. Oncotarget. 2017. PMID: 29108223 Free PMC article. No abstract available.
Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase.
Reckel S, Gehin C, Tardivon D, Georgeon S, Kükenshöner T, Löhr F, Koide A, Buchner L, Panjkovich A, Reynaud A, Pinho S, Gerig B, Svergun D, Pojer F, Güntert P, Dötsch V, Koide S, Gavin AC, Hantschel O. Reckel S, et al. Among authors: hantschel o. Nat Commun. 2017 Dec 13;8(1):2101. doi: 10.1038/s41467-017-02313-6. Nat Commun. 2017. PMID: 29235475 Free PMC article.
Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms.
Duarte DP, Lamontanara AJ, La Sala G, Jeong S, Sohn YK, Panjkovich A, Georgeon S, Kükenshöner T, Marcaida MJ, Pojer F, De Vivo M, Svergun D, Kim HS, Dal Peraro M, Hantschel O. Duarte DP, et al. Among authors: hantschel o. Nat Commun. 2020 May 8;11(1):2319. doi: 10.1038/s41467-020-16128-5. Nat Commun. 2020. PMID: 32385234 Free PMC article.
79 results