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Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition.
Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-DeMotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA. Jaeger LB, et al. Among authors: farr sa. J Alzheimers Dis. 2009;17(3):553-70. doi: 10.3233/JAD-2009-1074. J Alzheimers Dis. 2009. PMID: 19433890 Free PMC article.
Extra virgin olive oil improves learning and memory in SAMP8 mice.
Farr SA, Price TO, Dominguez LJ, Motisi A, Saiano F, Niehoff ML, Morley JE, Banks WA, Ercal N, Barbagallo M. Farr SA, et al. J Alzheimers Dis. 2012;28(1):81-92. doi: 10.3233/JAD-2011-110662. J Alzheimers Dis. 2012. PMID: 21955812
Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study.
Fiorini A, Sultana R, Förster S, Perluigi M, Cenini G, Cini C, Cai J, Klein JB, Farr SA, Niehoff ML, Morley JE, Kumar VB, Butterfield DA. Fiorini A, et al. Among authors: farr sa. Free Radic Biol Med. 2013 Dec;65:1-14. doi: 10.1016/j.freeradbiomed.2013.06.017. Epub 2013 Jun 15. Free Radic Biol Med. 2013. PMID: 23777706 Free PMC article.
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.
Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TL, Murphy MP, Morley JE, Kumar V, Butterfield DA. Farr SA, et al. Free Radic Biol Med. 2014 Feb;67:387-95. doi: 10.1016/j.freeradbiomed.2013.11.014. Epub 2013 Dec 16. Free Radic Biol Med. 2014. PMID: 24355211 Free PMC article.
133 results