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Page 1
Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.
Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B. Manik MK, et al. Among authors: gu w. Science. 2022 Sep 30;377(6614):eadc8969. doi: 10.1126/science.adc8969. Epub 2022 Sep 30. Science. 2022. PMID: 36048923
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai JS, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN, Kobe B. Horsefield S, et al. Among authors: gu w. Science. 2019 Aug 23;365(6455):793-799. doi: 10.1126/science.aax1911. Science. 2019. PMID: 31439792
SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.
Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Figley MD, et al. Among authors: gu w. Neuron. 2021 Apr 7;109(7):1118-1136.e11. doi: 10.1016/j.neuron.2021.02.009. Epub 2021 Mar 2. Neuron. 2021. PMID: 33657413 Free PMC article.
Structural Evolution of TIR-Domain Signalosomes.
Nimma S, Gu W, Maruta N, Li Y, Pan M, Saikot FK, Lim BYJ, McGuinness HY, Zaoti ZF, Li S, Desa S, Manik MK, Nanson JD, Kobe B. Nimma S, et al. Among authors: gu w. Front Immunol. 2021 Nov 17;12:784484. doi: 10.3389/fimmu.2021.784484. eCollection 2021. Front Immunol. 2021. PMID: 34868065 Free PMC article. Review.
Neurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Loreto A, Angeletti C, Gu W, Osborne A, Nieuwenhuis B, Gilley J, Merlini E, Arthur-Farraj P, Amici A, Luo Z, Hartley-Tassell L, Ve T, Desrochers LM, Wang Q, Kobe B, Orsomando G, Coleman MP. Loreto A, et al. Among authors: gu w. Elife. 2021 Dec 6;10:e72823. doi: 10.7554/eLife.72823. Elife. 2021. PMID: 34870595 Free PMC article.
Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules.
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T. Shi Y, et al. Among authors: gu w. Mol Cell. 2022 May 5;82(9):1643-1659.e10. doi: 10.1016/j.molcel.2022.03.007. Epub 2022 Mar 24. Mol Cell. 2022. PMID: 35334231 Free PMC article.
6,105 results