Xu H - Search Results

1

Discovery of Novel Imidazo[4,5-c]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Intestinal Homeostasis.

Liang X, Xie Y, Liu X, Xu H, Ren H, Tang S, Liu Q, Huang M, Shao X, Li C, Zhou Y, Geng M, Xie Z, Liu H. Liang X, et al. Among authors: xu h. J Med Chem. 2022 Sep 22;65(18):11949-11969. doi: 10.1021/acs.jmedchem.2c00390. Epub 2022 Sep 2. J Med Chem. 2022. PMID: 36053746

2

The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma.

Ai J, Tang Q, Wu Y, Xu Y, Feng T, Zhou R, Chen Y, Gao X, Zhu Q, Yue X, Pan Q, Xu S, Li J, Huang M, Daugherty-Holtrop J, He Y, Xu HE, Fan J, Ding J, Geng M. Ai J, et al. Among authors: xu he, xu s, xu y. J Natl Cancer Inst. 2011 Nov 16;103(22):1696-712. doi: 10.1093/jnci/djr360. Epub 2011 Oct 24. J Natl Cancer Inst. 2011. PMID: 22025622 Free PMC article.

3

Development of the First Generation of Disulfide-Based Subtype-Selective and Potent Covalent Pyruvate Dehydrogenase Kinase 1 (PDK1) Inhibitors.

Liu Y, Xie Z, Zhao D, Zhu J, Mao F, Tang S, Xu H, Luo C, Geng M, Huang M, Li J. Liu Y, et al. Among authors: xu h. J Med Chem. 2017 Mar 23;60(6):2227-2244. doi: 10.1021/acs.jmedchem.6b01245. Epub 2017 Mar 6. J Med Chem. 2017. PMID: 28230989

4

Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer.

Gao F, Chen X, Lu J, Hu S, Xu H, Shi Y, Feng M, Ding J, Liu H, Luo C, Xie Z, Wang J. Gao F, et al. Among authors: xu h. Eur J Med Chem. 2021 Apr 5;215:113274. doi: 10.1016/j.ejmech.2021.113274. Epub 2021 Feb 7. Eur J Med Chem. 2021. PMID: 33592537

5

HER2/PD1 bispecific antibody in IgG4 subclass with superior anti-tumour activities.

Chu W, Xu H, Wang Y, Xie Y, Chen YL, Tan X, Huang C, Wang G, Wang Q, Luo W, Xia N, Geng M, Xie Z, Wang C. Chu W, et al. Among authors: xu h. Clin Transl Med. 2022 Apr;12(4):e791. doi: 10.1002/ctm2.791. Clin Transl Med. 2022. PMID: 35384333 Free PMC article. No abstract available.

6

Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer.

Zhang S, Chen X, Wu C, Xu H, Xie X, Feng M, Hu S, Bai H, Gao F, Tong L, Ding J, Liu H, Xie Z, Wang J. Zhang S, et al. Among authors: xu h. J Med Chem. 2022 Jun 9;65(11):7697-7716. doi: 10.1021/acs.jmedchem.2c00040. Epub 2022 Apr 19. J Med Chem. 2022. PMID: 35439002

7

Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation.

Xie Z, Wang Z, Fan F, Zhou J, Hu Z, Wang Q, Wang X, Zeng Q, Zhang Y, Qiu J, Zhou X, Xu H, Bai H, Zhan Z, Ding J, Zhang H, Duan W, Yu X, Geng M. Xie Z, et al. Among authors: xu h. Cell Discov. 2022 Dec 13;8(1):133. doi: 10.1038/s41421-022-00481-4. Cell Discov. 2022. PMID: 36513640 Free PMC article.

8

Anti-inflammatory germacrane-type sesquiterpene lactones from Vernonia sylvatica.

Wang M, Li H, Hu B, Tang C, Xu H, Ke C, Xie Z, Ye Y, Yao S. Wang M, et al. Among authors: xu h. Chin J Nat Med. 2024 Jun;22(6):568-576. doi: 10.1016/S1875-5364(24)60656-4. Chin J Nat Med. 2024. PMID: 38906603

9

Comparison of "framework Shuffling" and "CDR Grafting" in humanization of a PD-1 murine antibody.

Wang Y, Chen YL, Xu H, Rana GE, Tan X, He M, Jing Q, Wang Q, Wang G, Xie Z, Wang C. Wang Y, et al. Among authors: xu h. Front Immunol. 2024 Jul 15;15:1395854. doi: 10.3389/fimmu.2024.1395854. eCollection 2024. Front Immunol. 2024. PMID: 39076979 Free PMC article.

10

A DXd/TLR7-Agonist Dual-Conjugate Anti-HER2 ADC Exerts Robust Antitumor Activity Through Tumor Cell Killing and Immune Activation.

Yue H, Xu H, Ma L, Li X, Yang B, Wang X, Zeng Q, Li H, Zhang D, Geng M, Meng T, Xie Z. Yue H, et al. Among authors: xu h. Mol Cancer Ther. 2024 Nov 4;23(11):1639-1651. doi: 10.1158/1535-7163.MCT-24-0078. Mol Cancer Ther. 2024. PMID: 39082754

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