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First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis.
Karimaa M, Riikonen R, Kettunen H, Taavitsainen P, Ramela M, Chrusciel M, Karlsson S, Rummakko P, Simola O, Wohlfahrt G, Hakulinen P, Vuorela A, Joensuu H, Utriainen T, Fizazi K, Oksala R. Karimaa M, et al. Among authors: hakulinen p. Mol Cancer Ther. 2022 Dec 2;21(12):1765-1776. doi: 10.1158/1535-7163.MCT-22-0115. Mol Cancer Ther. 2022. PMID: 36129801
Phase I/IIa, open-label, multicentre study to evaluate the optimal dosing and safety of ODM-203 in patients with advanced or metastatic solid tumours.
Bono P, Massard C, Peltola KJ, Azaro A, Italiano A, Kristeleit RS, Curigliano G, Lassen U, Arkenau HT, Hakulinen P, Garratt C, Ikonen T, Mustonen MVJ, Rodon JA. Bono P, et al. Among authors: hakulinen p. ESMO Open. 2020 Dec;5(6):e001081. doi: 10.1136/esmoopen-2020-001081. ESMO Open. 2020. PMID: 33262202 Free PMC article. Clinical Trial.
A double-blind, randomized, placebo-controlled crossover trial of the α2C-adrenoceptor antagonist ORM-12741 for prevention of cold-induced vasospasm in patients with systemic sclerosis.
Herrick AL, Murray AK, Ruck A, Rouru J, Moore TL, Whiteside J, Hakulinen P, Wigley F, Snapir A. Herrick AL, et al. Among authors: hakulinen p. Rheumatology (Oxford). 2014 May;53(5):948-52. doi: 10.1093/rheumatology/ket421. Epub 2014 Jan 31. Rheumatology (Oxford). 2014. PMID: 24489014 Clinical Trial.
Toxicological profile of cereulide, the Bacillus cereus emetic toxin, in functional assays with human, animal and bacterial cells.
Andersson MA, Hakulinen P, Honkalampi-Hämäläinen U, Hoornstra D, Lhuguenot JC, Mäki-Paakkanen J, Savolainen M, Severin I, Stammati AL, Turco L, Weber A, von Wright A, Zucco F, Salkinoja-Salonen M. Andersson MA, et al. Among authors: hakulinen p. Toxicon. 2007 Mar 1;49(3):351-67. doi: 10.1016/j.toxicon.2006.10.006. Epub 2006 Oct 27. Toxicon. 2007. PMID: 17156808
23 results