Gmeiner P - Search Results

1

Structure-based discovery of nonopioid analgesics acting through the α_2A-adrenergic receptor.

Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P. Fink EA, et al. Among authors: gmeiner p. Science. 2022 Sep 30;377(6614):eabn7065. doi: 10.1126/science.abn7065. Epub 2022 Sep 30. Science. 2022. PMID: 36173843 Free PMC article.

2

Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.

Löber S, Hübner H, Gmeiner P. Löber S, et al. Among authors: gmeiner p. Bioorg Med Chem Lett. 1999 Jan 4;9(1):97-102. doi: 10.1016/s0960-894x(98)00692-1. Bioorg Med Chem Lett. 1999. PMID: 9990464

3

Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.

Thomas C, Hübner H, Gmeiner P. Thomas C, et al. Among authors: gmeiner p. Bioorg Med Chem Lett. 1999 Mar 22;9(6):841-6. doi: 10.1016/s0960-894x(99)00086-4. Bioorg Med Chem Lett. 1999. PMID: 10206547

4

2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

Haubmann C, Hübner H, Gmeiner P. Haubmann C, et al. Among authors: gmeiner p. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1969-72. doi: 10.1016/s0960-894x(99)00302-9. Bioorg Med Chem Lett. 1999. PMID: 10450964

5

Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.

Haubmann C, Hübner H, Gmeiner P. Haubmann C, et al. Among authors: gmeiner p. Bioorg Med Chem Lett. 1999 Nov 1;9(21):3143-6. doi: 10.1016/s0960-894x(99)00540-5. Bioorg Med Chem Lett. 1999. PMID: 10560741

6

Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.

Hübner H, Haubmann C, Utz W, Gmeiner P. Hübner H, et al. Among authors: gmeiner p. J Med Chem. 2000 Feb 24;43(4):756-62. doi: 10.1021/jm991098z. J Med Chem. 2000. PMID: 10691700

7

Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.

Einsiedel J, Thomas C, Hübner H, Gmeiner P. Einsiedel J, et al. Among authors: gmeiner p. Bioorg Med Chem Lett. 2000 Sep 4;10(17):2041-4. doi: 10.1016/s0960-894x(00)00405-4. Bioorg Med Chem Lett. 2000. PMID: 10987445

8

Azepino- and diazepinoindoles: synthesis and dopamine receptor binding profiles.

Kraxner J, Hübner H, Gmeiner P. Kraxner J, et al. Among authors: gmeiner p. Arch Pharm (Weinheim). 2000 Sep;333(9):287-92. doi: 10.1002/1521-4184(20009)333:9<287::aid-ardp287>3.0.co;2-r. Arch Pharm (Weinheim). 2000. PMID: 11039184

9

Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.

Hübner H, Kraxner J, Gmeiner P. Hübner H, et al. Among authors: gmeiner p. J Med Chem. 2000 Nov 16;43(23):4563-9. doi: 10.1021/jm0009989. J Med Chem. 2000. PMID: 11087581

10

Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).

Löber S, Hübner H, Utz W, Gmeiner P. Löber S, et al. Among authors: gmeiner p. J Med Chem. 2001 Aug 16;44(17):2691-4. doi: 10.1021/jm015522j. J Med Chem. 2001. PMID: 11495580

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