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Page 1
Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout.
Steimbach RR, Herbst-Gervasoni CJ, Lechner S, Stewart TM, Klinke G, Ridinger J, Géraldy MNE, Tihanyi G, Foley JR, Uhrig U, Kuster B, Poschet G, Casero RA Jr, Médard G, Oehme I, Christianson DW, Gunkel N, Miller AK. Steimbach RR, et al. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875. doi: 10.1021/jacs.2c05030. Epub 2022 Oct 6. J Am Chem Soc. 2022. PMID: 36200994 Free PMC article.
Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors.
Morgen M, Steimbach RR, Géraldy M, Hellweg L, Sehr P, Ridinger J, Witt O, Oehme I, Herbst-Gervasoni CJ, Osko JD, Porter NJ, Christianson DW, Gunkel N, Miller AK. Morgen M, et al. Among authors: steimbach rr. ChemMedChem. 2020 Jul 3;15(13):1163-1174. doi: 10.1002/cmdc.202000149. Epub 2020 May 13. ChemMedChem. 2020. PMID: 32348628 Free PMC article.
Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.
Lechner S, Malgapo MIP, Grätz C, Steimbach RR, Baron A, Rüther P, Nadal S, Stumpf C, Loos C, Ku X, Prokofeva P, Lautenbacher L, Heimburg T, Würf V, Meng C, Wilhelm M, Sippl W, Kleigrewe K, Pauling JK, Kramer K, Miller AK, Pfaffl MW, Linder ME, Kuster B, Médard G. Lechner S, et al. Among authors: steimbach rr. Nat Chem Biol. 2022 Aug;18(8):812-820. doi: 10.1038/s41589-022-01015-5. Epub 2022 Apr 28. Nat Chem Biol. 2022. PMID: 35484434 Free PMC article.
First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement.
Herp D, Ridinger J, Robaa D, Shinsky SA, Schmidtkunz K, Yesiloglu TZ, Bayer T, Steimbach RR, Herbst-Gervasoni CJ, Merz A, Romier C, Sehr P, Gunkel N, Miller AK, Christianson DW, Oehme I, Sippl W, Jung M. Herp D, et al. Among authors: steimbach rr. Chembiochem. 2022 Jul 19;23(14):e202200180. doi: 10.1002/cbic.202200180. Epub 2022 Jun 10. Chembiochem. 2022. PMID: 35608330 Free PMC article.
Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.
Lechner S, Malgapo MIP, Grätz C, Steimbach RR, Baron A, Rüther P, Nadal S, Stumpf C, Loos C, Ku X, Prokofeva P, Lautenbacher L, Heimburg T, Würf V, Meng C, Wilhelm M, Sippl W, Kleigrewe K, Pauling JK, Kramer K, Miller AK, Pfaffl MW, Linder ME, Kuster B, Médard G. Lechner S, et al. Among authors: steimbach rr. Nat Chem Biol. 2022 Aug;18(8):913. doi: 10.1038/s41589-022-01112-5. Nat Chem Biol. 2022. PMID: 35840679 No abstract available.
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