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Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R).
Ferrisi R, Gado F, Polini B, Ricardi C, Mohamed KA, Stevenson LA, Ortore G, Rapposelli S, Saccomanni G, Pertwee RG, Laprairie RB, Manera C, Chiellini G. Ferrisi R, et al. Among authors: ricardi c. Front Chem. 2022 Sep 27;10:984069. doi: 10.3389/fchem.2022.984069. eCollection 2022. Front Chem. 2022. PMID: 36238097 Free PMC article.
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
Gado F, Ferrisi R, Polini B, Mohamed KA, Ricardi C, Lucarini E, Carpi S, Domenichini F, Stevenson LA, Rapposelli S, Saccomanni G, Nieri P, Ortore G, Pertwee RG, Ghelardini C, Di Cesare Mannelli L, Chiellini G, Laprairie RB, Manera C. Gado F, et al. Among authors: ricardi c. J Med Chem. 2022 Jul 28;65(14):9918-9938. doi: 10.1021/acs.jmedchem.2c00582. Epub 2022 Jul 18. J Med Chem. 2022. PMID: 35849804 Free PMC article.
New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2.
Ferrisi R, Polini B, Ricardi C, Gado F, Mohamed KA, Baron G, Faiella S, Poli G, Rapposelli S, Saccomanni G, Aldini G, Chiellini G, Laprairie RB, Manera C, Ortore G. Ferrisi R, et al. Among authors: ricardi c. Int J Mol Sci. 2023 Jan 21;24(3):2135. doi: 10.3390/ijms24032135. Int J Mol Sci. 2023. PMID: 36768458 Free PMC article.
A Proteomic Approach Identified TFEB as a Key Player in the Protective Action of Novel CB2R Bitopic Ligand FD22a against the Deleterious Effects Induced by β-Amyloid in Glial Cells.
Polini B, Zallocco L, Gado F, Ferrisi R, Ricardi C, Zuccarini M, Carnicelli V, Manera C, Ronci M, Lucacchini A, Zucchi R, Giusti L, Chiellini G. Polini B, et al. Among authors: ricardi c. Cells. 2024 May 19;13(10):875. doi: 10.3390/cells13100875. Cells. 2024. PMID: 38786097 Free PMC article.